Chapter 10 Flashcards
(34 cards)
Multicellular
Organisms composed of more than one cell
Multicellular organisms
Organisms composed of more than one cell
Main benefit from the division of labor
Larger genomes = larger proteomes
Additional proteins used for:
- Cell communication
- Arrangement and attachment of cells
- Cell specialization
Extracellular Matrix and Cell Walls
Extracellular Matrix (ECM)
Network of material secreted from the cells forming a complex meshwork outside of cells
Major component of certain parts of plants and animals:
Bone and cartilage of animals
Woody parts of plants
The major macromolecules of the ECM
proteins and polysaccharides
Extracellular Matrix and Cell Walls - Compoents
Animal cells secrete ECM that helps to support and organize cells
Major macromolecules are proteins and polysaccharides
Proteins form large fibers
Polysaccharides give a gel-like character
Extracellular Matrix and Cell Walls - Compoents
Important roles
Strength and structural support
Tissue organization
Cell signaling
Proteins of ECM
Adhesive
Fibronectin and laminin
Adhere ECM components together and to the cell surface
Proteins of ECM
Structural
Collagen provides tensile strength
Main protein found in bone, cartilage, tendon, skin
Elastin provides elasticity
Expands and returns to original shape
elastin
A protein that makes up elastic fibers in the extracellular matrix of animals.
glycosaminoglycan (GAG)
The most abundant type of polysaccharide in the extracellular matrix (ECM) of animals, consisting of repeating disaccharide units that give a gel-like character to the ECM.
proteoglycan
A long, linear core protein with many GAGs attached to it; found in the ECM.
Polysaccharides in animal ECM
After proteins, 2nd major component of ECM
In vertebrates, the most abundant are glycosaminoglycans (GAGs)
1. Long, unbranched polysaccharides with a repeating disaccharide unit
2. Highly negatively charge attracts positive ions and water
Glycosaminoglycans in animal ECM
GAGs and proteoglycans resist compression
Form gel-like component
Two GAG examples:
Chondroitin sulfate – cartilage
Hyaluronic acid – found in skin, eyes, joint fluid
Chitin important in ECM for invertebrates
Exoskeleton of arthropods
chitin
A tough, nitrogen-containing polysaccharide that forms the external skeleton of many insects and crustaceans and is found in the cell walls of fungi.
cellulose
The main macromolecule of the cell wall of plants and many algae; a linear polymer made of thousands of glucose monomers.
Plant cell walls
Protective cell wall outside the plasma membrane
Rigidity for mechanical support
Maintenance of cell shape
Direction of cell growth
Usually stronger, thicker and more rigid than ECM than in animals
The cell wall of plants are composed of a primary cell wall and secondary cell wall
- The primary cell wall is thin and flexible. It contains cellulose microfibrils in a meshwork pattern, along with other components shown on the far right.
- The secondary cell wall is made in successive layers. Each layer contains strong cellulose microfibrils in parallel arrays. The direction of cellulose microfibrils in each layer is varied, as shown on the right.
Cell Junctions
Adhere cells to each other and to the ECM
Animals cells have a more varied group of junctions
In plants, cellular organization is different because of the rigid cell wall
Anchoring Junctions (Animal Cells)
Attach cells to each other and to the ECM
Rely on cell adhesion molecules (CAMs)
Cadherin
Integrin
Cadherins
Extracellular domain of two cadherins, each in adjacent cells, bind to each other to promote cell-to-cell adhesion
Inside the cell, linker proteins connect cadherins to the cytoskeleton
By expressing only certain types of cadherins, each cell will only bind to other expressing same type
Integrins
Group of cell-surface receptor proteins
1. 2nd type of CAMs
2. Creates connections between cells and ECM
3. Do not require Ca2+ to function
4. Extracellular domain to bind to ECM
5. Intracellular domain for binding to cytoskeleton
Tight Junctions in Animals
Also known as occluding junctions
Forms tight seal between adjacent cells
Prevents ECM from leaking between cells
Tight junctions:
Made by occludin and claudin
Bind to each to form tight seal
Not mechanically strong, not bound to cytoskeleton