Chapter 11 diseases of upper and lower respiratory system Flashcards
(54 cards)
The movement of mucus from lungs to pharynx is due to…
Ciliary escalators
Is normal microbiota found in the upper or lower respiratory system?
Upper RS
What is the significance of the open connections between the nasopharyx, estachian tube and nasolacrimal ducts?
they allow microorganisms to move from the sinuses and middle ears down into the lower respiratory tract
Streptococcal Pharyngitis
- Pathogen: Group A streptococci (S. pyogenes).
- Signs and Symptoms: Sore throat, difficulty swallowing, swollen lymph nodes, purulent abscesses, fever, malaise, headache.
- Pathogenesis/Epidemiology/Transmission: Spread via respiratory droplets; occurs in winter and spring; requires large inoculum or weakened immunity.
Diphtheria
- Pathogen: Corynebacterium diphtheriae.
- Signs and Symptoms: Sore throat, localized pain, fever, pseudo membrane formation.
- Pathogenesis/Epidemiology/Transmission: Spread via respiratory droplets or skin contact; affects immunocompromised individuals.
Rhinosinusitis
- Pathogen: Streptococcus pneumoniae (35%).
- Signs and Symptoms: Inflammation of sinus tissue, malaise, headache, nasal inflammation.
- Pathogenesis/Epidemiology/Transmission: Bacteria spread from the throat to sinuses; more common in adults.
Otitis Media (Ear Infection)
* Pathogen: Streptococcus pneumoniae (35%).
* Signs and Symptoms: Severe ear pain, fluid buildup (effusion), pressure in the middle ear.
* Pathogenesis/Epidemiology/Transmission: More common in children; severe cases may require drainage or surgery.
Otitis Media
- Pathogen: Streptococcus pneumoniae (35%).
- Signs and Symptoms: Severe ear pain, fluid buildup (effusion), pressure in the middle ear.
- Pathogenesis/Epidemiology/Transmission: More common in children; severe cases may require drainage or surgery.
Def: Laryngitis
Vocal cord inflammation, causing soreness and hoarse voice
What are the 4 possible complications of Streptococcal Pharyngitis
- Laryngitis
- Bronchitis
- Scarlet Fever
- Rheumatic Fever
Def: Bronchitis
Inflammation of bronchial tubes, can be acute or chronic. Creates painful breathing
Def: Scarlet Fever
Fever, rash spreading on chest, tongue becomes strawberry red
Def: Rheumatic Fever
Inflammation leads to damage of heart valves and muscle. An autoimmune response
Common Cold
- Pathogen: Over 200 viruses, primarily enteroviruses (rhinoviruses), coronaviruses, adenoviruses.
- Signs and Symptoms: Sneezing, runny nose, congestion, sore throat, malaise, cough (no fever).
- Pathogenesis/Epidemiology/Transmission: Highly infective; spreads via droplets, fomites, and direct contact.
Why is immunity to the common cold so difficult to develop? explain
Because there are over 200 strands of the virus, and creating a vaccine to stop all of them has not been done yet
Pneumococcal Pneumonia
- Pathogen: Streptococcus pneumoniae.
- Signs and Symptoms: Fever, chills, congestion, cough, chest pain, rust-colored sputum, rapid breathing.
- Pathogenesis/Epidemiology/Transmission: Bacteria inhaled; replication damages lungs.
Klebsiella Pneumonia
- Pathogen: Klebsiella pneumoniae.
- Signs and Symptoms: Pneumonia with bloody sputum, chills.
- Pathogenesis/Epidemiology/Transmission: Inhalation; higher risk in immunocompromised individuals.
Legionnaire’s Disease
- Pathogen: Legionella pneumophila.
- Signs and Symptoms: Pneumonia symptoms, pleurisy, GI, CNS, kidney, liver complications.
- Pathogenesis/Epidemiology/Transmission: Found in water systems; thrives in protozoa and biofilms.
Tuberculosis(TB)
- Pathogen: Mycobacterium tuberculosis.
- Signs and Symptoms: Chronic cough, mild fever, fatigue, weight loss, blood in sputum.
- Pathogenesis/Epidemiology/Transmission: Low infectious dose; survives in phagocytes due to waxy cell wall.
Pertussis(Whooping Cough)
- Pathogen: Bordetella pertussis.
- Signs and Symptoms: Cold-like symptoms, progressing to violent coughing spells (“whoop”).
- Pathogenesis/Epidemiology/Transmission: Attaches to cilia, releases toxins, and kills epithelial cells.
Inhalation Anthrax
- Pathogen: Bacillus anthracis.
- Signs and Symptoms: Initially flu-like, progressing to severe cough, lethargy, shock, and death.
- Pathogenesis/Epidemiology/Transmission: Inhalation of endospores; spores germinate and release anthrax toxin.
Name the four stages of Pertussis: “I can’t play Cod” - give some details of each step
- Incubation - Last 7-10 days
- Catarrhal - Last 1-2 weeks, like the common cold
- Paroxysmal - 3-4 weeks, violent coughing spells
- Convalescent - last several weeks as cough subsides
Tuberculosis tree:
Begins with inhalation of ______________
Establishing ___________
Diagnosed by_____________ and __________
Treatment is hampered by_____________
Explemplified by ________ and ________
- M. Tuberculosis
- Primary Infection
- Chest x-ray and TB skin test
- Antibiotic Resistance
- XDR-TB and MDR-TB
what is the significance of a positive TB skin test? what does it look like?
Indicates if the microbe is present, but does not necissarily mean it is active
It is a hard, red lesion
Influenza
- Pathogen: Orthomyxovirus (Influenza types A and B).
- Signs and Symptoms: Fever, cough, myalgia, congestion; susceptible to secondary infections.
- Pathogenesis/Epidemiology/Transmission: Damages lung epithelium; requires yearly vaccination due to mutations.