Chapter 11: Necrosis and Apoptosis

Question 1

What is necrosis?

Answer 1

Necrosis is involuntary, toxic,
inflammatory and can release
harmful chemicals into extracellular
fluid

Question 2

What is apoptosis?

Answer 2

Apoptosis occurs in a careful,
coordinated manner that minimizes
damage to surrounding tissues

Question 3

Why does necrosis occur?

Answer 3

Necrosis generally occurs when
cell death occurs as a result of
injury/disease

Question 4

What does necrosis lead to?

Answer 4

uncontrolled release of
antigens that trigger an
inflammatory response

Question 5

How does apoptosis occur?

Answer 5

Molecular pathways are triggered that induce the
cell to undergo a careful and deliberate breakdown

Question 6

When does apoptosis occur?

Answer 6

Occurs during viral infection, development, lack of
blood supply, damage or when cell has reached the
end of its lifespan

Question 7

Does apoptosis leave any sign of damage?

Answer 7

Leaves no trace of damage on cellular landscape

Question 8

What else is apoptosis useful for?

Answer 8

Development: Formation of many physical features as well as our
brain development occur via apoptosis

Question 9

Outline the steps of apoptosis.

Answer 9

• The cell shrinks and becomes lobed (blebbing)
• As cell fragmentation occurs, the cell contents
  (monomers, metabolized cell components) are
  sealed into small sacs called apoptotic bodies
• These apoptotic bodies can be further broken
  down, recycled or used to communicate with
  neighboring cells

Question 10

How is apoptosis triggered?

Answer 10

Extracellular or intracellular signals

Question 11

Which proteins are involved in apoptosis signaling?

Answer 11

Caspases