Chapter 13+14 Flashcards

(252 cards)

1
Q

Colony-stimulating factor (CSF)

A

Protein that stimulates growth of white blood cells

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2
Q

Differentiation

A

change in structure and function of a cell as it matures; specialization

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3
Q

electrophoresis

A

A method of separating serum proteins by electrical charge

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4
Q

eosinophil

A

White blood cell that contains granules that stain red

phagocytic cells involved in allergic responses and parasitic infections

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5
Q

erythroblast

A

An immature red blood cell

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6
Q

erythrocyte

A

Red blood cell

-transports oxygen

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7
Q

Erythropoietin

A

Hormone secreted by kidneys that stimulates red blood cell formation

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8
Q

Fibrin

A

Protein that forms basis of blood clot

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9
Q

Fibrinogen

A

Plasma protein that is converted to fibrin in clotting process

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10
Q

globulin

A

Plasma protein, separated into alpha, beta, and gamma

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11
Q

granulocyte

A

White blood cell with numerous dark-staining granules

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12
Q

Hematopoietic stem cell

A

Cell in bone marrow that gives rise to all types of blood cells

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13
Q

hemoglobin

A

Blood protein containing iron; carries oxygen in red blood cells

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14
Q

heparin

A

An anticoagulant found in blood and tissue cells

-used against congestive heart failure

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15
Q

Immune reaction

A

Response of immune system to foreign invasion

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16
Q

immunoglobulin

A

Protein with antibody activity

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17
Q

leukocyte

A

White blood cell

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18
Q

lymphocyte

A

Mononuclear leukocyte that produces antibodies

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19
Q

macrophage

A

Monocyte that migrates from blood to tissue spaces; as a phagocyte, it engulfs foreign materials and debris; destroys worn out RBCs

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20
Q

Megakaryocyte

A

Large platelet precursor cell found in bone marrow

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21
Q

monocyte

A
  • Leukocyte with one large nucleus; engulf foreign material and debris’ becomes macrophage
  • DEF2: Mononuclear white blood cell (agranulocyte) formed in lymph tissue; it is a phagocyte and the precursor to macrophage
  • digest bacteria and large tissue debris
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22
Q

mononuclear

A

Pertaining to cell (leukocyte) with single round nucleus

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23
Q

myeloblast

A

Immature bone marrow that gives rise to granulocytes

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24
Q

neutrophil

A

-Granulocytic leukocyte formed in bone marrow; polymorphonuclear

  • phagocytic cells that accumulate at sites of infection
  • do not stain, are white
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25
plasma
Liquid portion of blood; contains water, proteins, salts, nutrients, lipids, hormones, and vitamins
26
plasmapheresis
Removal of plasma from withdrawn blood by centrifuge
27
platelet
Small blood fragment important in clotting
28
polymorphonuclear
Pertaining to white blood cell with multi-shaped nucleus; neutrophil
29
prothrombin
Plasma protein; converted to thrombin in the clotting process
30
Reticulocyte
Immature erythrocyte
31
Rh factor
Antigen on red blood cells of Rh positive(RH+) individuals
32
Serum
Plasma minus clotting proteins and cells | -component of blood
33
Stem cell
Unspecialized cell that gives rise to mature, specialized forms
34
thrombin
Enzyme that converts fibrinogen to fibrin during coagulation
35
thrombocyte
platelets
36
Types of blood cells
- Erythrocytes - Thrombocytes (platelets) - Leukocytes
37
A Blood type
A antigen and anti-B antibody
38
B Blood Type
B antigen and anti-A antibody
39
AB blood type
A and B antigens and no antibodies (universal recipient)
40
O blood type
``` No A or B antigens, and both anti-A and anti-B antibodies (universal donor) Rh Factor (positive and negative) ```
41
Albumin
Protein in the blood; maintains proper amount of water in blood
42
Antibody (AB)
Specific protein produced by lymphocytes in response to bacteria, viruses, or other antigen
43
Antigen
A substance that stimulates production of an antibody
44
Basophil
- White blood cell that contains granules that stain blue | - contains heparin (prevents clotting and histamine(involved in allergic response)
45
Bilirubin
Orange-yellow pigment in bile; formed by breakdown of hemoglobin when RBCs are destroyed -piss is very yellow, could mean problems with spleen
46
Coagulation
Blood clotting
47
bas/o
base
48
chrom/o
color
49
coagul/o
clotting
50
cyt/o
cell
51
eosin/o
red, dawn, rosy
52
erythr/o
red
53
granul/o
granules
54
hem/o
blood
55
hemat/o
blood
56
hemoglobin/o
hemoglobin
57
is/o
same, equal
58
kary/o
nucleus
59
leuk/o
white
60
mon/o
one, single
61
morph/o
shape, form
62
myel/o
bone marrow
63
neutr/o
neutral
64
nucle/o
nucleus
65
phag/o
eat, swallow
66
poikil/o
varied, irregular
67
sider/o
iron
68
spher/o
globe, round
69
thromb/o
clot
70
Aplastic anemia
Failure of blood cell production due to aplasia of cell formation of bone marrow cells -prevalent in cancer (spleen, pancreatic, etc) body will just stop producing cells
71
Hemolytic anemia
Reduction in red cells due to excessive destruction
72
Pernicious anemia
Lack of mature erythrocytes caused by inability to absorb vitamin B12 into bloodstream -can take B12 orally to prevent this
73
Sickle cell anemia
Hereditary disorder of abnormal hemoglobin producing sickle shape erythrocytes and hemolysis
74
Thalassemia
Inherited defect in ability to produce hemoglobin, leading to hypochromia (blood loses color)
75
Hemochromatosis
Excess iron deposits throughout body. Can lead to congestive heart failure
76
Polycythemia Vera
General increase in red blood cells; can happen for no reason -treatment is to take blood out and throw it away
77
Hemophilia
-Excessive bleeding caused by hereditary factors VIII and IX necessary for blood clotting - Patients often bleed into weight-bearing joints, especially ankles and knees - very rare, mostly DMAB affected
78
Purpura
Multiple pinpoint hemorrhages and accumulation of blood under the skin
79
Leukemia
Increase in cancerous white blood cells
80
Granulocytosis
Abnormal increase in granulocytes in blood
81
Mononucleosis
Infectious disease marked by increased numbers of mononuclear leukocytes and enlarged cervical lymph nodes - no symptoms, maybe a wart or something - transferred between sexual contact/kissing
82
Multiple myeloma
Malignant neoplasm of bone marrow Malignant cells (lymphocytes called plasma cells that produce antibodies) destroy bone tissue and cause overproduction of immunoglobulins, including bence jones protein -found by taking urine test
83
Apheresis
Separation of blood into component parts and removal of select part from blood
84
Blood transfusion
Whole blood or cells taken from a donor and infused into a patient
85
Bone Marrow Biopsy
Microscopic exam of a core of bone marrow removed with a needle
86
Hematopoietic Stem Cell transplantation
Peripheral stem cells from a compatible donor administered into a recipient
87
Adaptive imunity
ability to recognize and remember specific antigens and mount an attack on them
88
Adenoids
Mass of lymphatic tissue in nasopharynx
89
antibody
protein produced by B cells to destroy antigens
90
antigen
foreign substance; evokes an immune response
91
Axillary nodes
lymph nodes in armpit
92
B Cell (B lymphocyte)
lymphocyte that matures into a plasma cell to secrete antibodies, mature in bone marrow
93
Cell-mediated immunity
T cells that respond to antigens and destroy them
94
Cervical Nodes
lymph nodes in neck region
95
complement system
proteins in blood that help antibodies and kill target
96
cytokines
proteins secreted by cytotoxic T cells to aid in antigen destruction
97
Cytotoxic T cell (CD8+ T cell)
lymphocyte that directly kills antigens
98
Dendritic Cell
antigen-presenting cell; shows T and B cells what to attack
99
Helper T cell (CD4+ T Cell)
Lymphocyte that aids B calls and stimulated T cells
100
Humoral immunity
- B cells produce antibodies after exposure to specific antigens; type of adaptive immunity - originate in bone marrow from stem cells - b cells mature into plasma cell that produces antibodies called immunoglobins to block effects of antigens
101
immunity
- body's ability to resist foreign organisms and toxins that damage tissues and organs - use of immune cells; antibodies, or vaccines to treat or prevent disease
102
immunoglobulins
antibodies secreted by plasma cells in response to the presence of an antigen
103
Immunotherapy
use of immune cells, antibodies, or vaccines to treat or prevent disease
104
inguinal nodes
lymph nodes in groin region
105
interferons
proteins secreted by T cells and other cells to aid and regulate the immune response
106
interleukins
proteins that stimulate gr | owth of B and T lymphocytes
107
Interstitial fluid
fluid in spaces between cells; becomes lymph in lymph capillaries
108
lymph
thin, watery fluid within lymphatic vessels and collected from tissues throughout the body
109
lymph capillaries
tiniest lymphatic vessels
110
lymphoid organs
lymph nodes, spleen, and thymus gland
111
lymph node
collection of stationary solid lymphatic tissue along lymph vessels
112
lymph vessel
carrier of lymph throughout the body
113
Macrophage
large phagocyte found in lymph nodes and other tissues of the body
114
mediastinal nodes
lymph nodes in the area between lungs in thoracic cavity
115
mesenteric nodes
lymph nodes in mesentery
116
monoclonal antibody (MoAV)
an antibody produced in a lab to attack antigens and destroy cells
117
natural immunity
protection that an individual is born with to fight infection; not dependent on prior exposure to antigen -Natural Killer cells present
118
paraaortic nodes
lymph nodes near aorta in lumbar area of body
119
Plasma cell
lymphocyte that secretes antibodies; matures from B lymphocytes
120
Right lymphatic duct
Vessel in chest that drains lymph from upper right part of body; empties into large neck vein
121
Spleen
Organ in left upper quadrant of abdomen that destroys worn-out RBCs, activates lymphocytes and stores blood
122
Suppressor T Cell (Treg)
lymphocyte that inhibits the activity of B and T cells
123
T cell (T lymphocytes)
lymphocyte that acts directly on antigens to destroy (attack) them or produces chemicals toxic to antigens
124
tolerance
Ability of T lyphocytes to recognize and accept the body's own antigens as "self" or friendly
125
thoracic duct
draining lymph from lower and left side of body; empties into large veins in neck
126
thymus gland
lymphoid organ in mediastinum that conditions T cells to react to foreign cells
127
tonsils
masses of lymphatic tissue in back of oropharynx
128
toxin
Poison; produced by certain bacteria, animals, or plants
129
Vaccination
exposure of individual to antigen that provokes an immune response that will destroy any cell with the antigen and will protect against infection
130
Vaccine
- stimulate patient's own T cells to recognize and kill cancerous cells - weakened or killed microorganisms, toxins, or other proteins given to induce immunity to infection or disease
131
immun/o
protection
132
lymph/o
lymph
133
lymphaden/o
lymph node
134
splen/o
spleen
135
thym/o
thymus gland
136
tox/o
poison
137
ana-
again, anew
138
inter-
between
139
axill/o
armpit
140
cervic/o
neck, cervix (neck of uterus)
141
inguin/o
groin
142
-cytosis
condition of cells; slight increase in numbers
143
-edema
swelling
144
-globulin
protein
145
-megaly
enlargement
146
-oid
resembling
147
-pathy
disease
148
-penia
deficiency
149
-phylaxis
protection
150
-poiesis
formation
151
-stitial
to set; pertaining to standing or positioned
152
-suppression
to stop
153
ana-
up; apart; backward; again; new
154
auto-
self; own
155
hyper-
above; excessive
156
inter-
between
157
retro-
behind; back; backward
158
AIDS
Acquired immunodeficiency Syndrome treated with Reverse Transcriptase Inhibitors (RTI), Protein inhibitors, HAART
159
Reverse Transcriptase Inhibitors (RTI)
- Inhibit viral enzyme called reverse transcriptase | - used to treat AIDS
160
Protein inhibitors
Inhibit Viral Proteolytic enzyme used to treat AIDS
161
HAART (Highly Active Antiretroviral Therapy)
combo of RTI and protease inhibitors
162
Allergy
Abnormal sensitivity acquired by exposure to antigen | -ranges from allergic rhinitis or hay fever to anaphylaxix
163
Tumor Lymphoma
malignant tumor of lymph node and lymph tissue
164
Multiple Myeloma
Malignant tumor of bone marrow cells
165
Thyoma
malignant tumor of thymus, associated with myasthenia gravis, can have other autoimmune disorders
166
CD4+ cell count
Measures number of CD4+ cells (helper T cells) in the bloodstream with patients with AIDS
167
ELISA test
detects anti-HIV antibodies; western blot given as follow-up
168
Immunoelectrophoresis
separates immunoglobulins (lgG, lgM, lgE, igA, igD)
169
Viral Load Test
Measures amount of aids virus in bloodstream
170
Computed Tomography (CT) Scan
X-ray imaging produces cross-sectional and other views of anatomic structures -show abnormalities of lymphoid organs, such as lymph nodes, spleen, thymus gland
171
ALL
Acute Lymphoid Leukemia
172
Acute Myeloid Leukemia (AML)
- Immature granulocytes (myeloblasts) predominate (Kids) | - platelets and erythrocytes are diminished because of infiltration and replacement of bone marrow by myeloblasts
173
Acute Lymphoid Leukemia (ALL)
- children/adolescents affected - immature lymphocytes (lymphoblasts) predominate, malignant condition of white blood cell - onset is sudden
174
Chronic Myeloid Leukemia (CML)
- Malignant condition of white blood cells/ both mature and immature granulocytes are present, older people 55+ - slowly progressive illness, can live many years without problems - treated with Gleevec
175
Gleevec
- used to treat Chronic Myeloid Leukemia | - targets abnormal proteins responsible for malignancy and produce long-term control
176
Chronic Lymphoid Leukemia (CLL)
- progressive course that mostly affects old people and doesn't require immediate treatment - abnormal numbers of relatively mature lymphocytes predominate in marrow, lymph nodes, and spleen
177
Antiglobulin Test (Coombs Test)
Test for presence of antibodies that can damage erythrocytes
178
Bleeding Time
Time required for blood to stop flowing from tiny puncture | -normal time is 8 min or less
179
Coagulation Time
Time required for venous blood to clot in test tube | -normal time less than 15 min
180
Complete Blood Cuont (CBC)
Determination of numbers of blood cells, homoglobin concentration, hematocrit, and red cell values - MCH, MCV, MCHC
181
MCH
Mean corpuscular hemoglobin
182
MCV
Mean corpuscular volume
183
MCHC
Mean corpuscular hemoglobin concentration
184
Erythrocyte Sedimentation Rate (ESR)
Speed for erythrocytes settle out of plasma
185
Hematocrit (Hct)
Percentage of erythrocytes in volume of blood -separation of blood so that percentage of red blood cells in relation to volume of blood sample is measured
186
Hemoglobin test (H, Hg, Hgb)
Total amount of hemoglobin in sample of peripheral blood
187
Platelet count
Number of platelets/clotting cells per cubic millimeter (mm^3) or microliter (uL) of blood
188
Partial thromboplastin time (PTT)
Measures other clotting factors
189
Prothrombin time (PT)
- Test of ability of blood to clot | - Used to monitor patients taking anticoagulant drugs
190
Red Blood Cell Count (RBC)
Number of erythtocytes per cubic millimeter (mm^3) or microliter (uL) of blood
191
Red blood cell (RBC) morphology
Microscopic exam of stained blood smear to determine the shape of individual red cells
192
White Blood cell count (WBC)
Number of leukocytes per cubic millimeter (mm^3) or microliter (uL) of blood
193
White Blood Cell Differential
percentages of different types of leukocytes in blood
194
Lymph node locations
Cervical, Axillary, Mediastinal, Mesenteric (intestinal), Paraaortic (lumbar), Inguinal (groin)
195
Spleen
- destroys old red blood cells - filters microorganisms and other foreign material out of blood - activates lymphocytes during blood filtration (Activates B cells and T cells) - stores blood, especially erythrocytes (RBCs) and platelets
196
Thymus Gland
- Provides immunity in fetal life and early years of growth - located at mediastinum area - early removal from animal impairs ability to make antibodies
197
Adaptive immunity
body's ability to recognize and remember specific antigens in an immune response
198
Cell Mediated immunity
- type of adaptive immunity - Cytotoxic T cells (T cells + CD8 cells) attach and directly kill antigens - other T cells secrete cytokines (interferons and interleukins) that help cells respond to antigens - Helper T cells (CD4+T Cells) promote antibody synthesis by B cells and stimulate other T cells; suppressor T cells make sure B and T cells don't attack good cells
199
Cytotixic Cells (CD8+T cells)
attach to and directly kill antigens in cell mediated immunity
200
Helper T cells (CD4+T cells)
promote antibody synthesis by B cells and stimulate other T cells in cell mediated immunity
201
Suppressor T cells (Regulatory T cell/Tregs)
inhibit B and T cells and prevent them from attacking body's good cells
202
Candidiasis
yeast-like infection, in mouth there will be white growth, called thrush, opportunistic infection with AIDS
203
Cryptococcus (crypto)
causes lung, brain, and blood infections, found in pigeon shit
204
Cryptosporidiosis
Parasitic infection of gastrointestinal tract and brain and spinal cord, found in farm animals
205
Cytomegalovirus (CMV) infection
virus causes enteritis and retinitis - only causes disease when immune system is compromised (like AIDS) - found in saliva, semen, cervical secretions, urine, feces, blood, and breast milk
206
Herpes Simplex
viral infection causes small blisters on skin of lips or nose or on genitals
207
Histoplasmosis (histo)
fungal infection caused by inhaling dust, causes fever, chils, and lung infection, -found in birds and bats
208
Myocobacterium Avium-intracellulare (MAI) infection
manifests with fever, malaise, night sweats, anorexia, diarrhea, weight loss, and lung/blood infections
209
Pneumocytis Pneumonia (PCP)
one-celled organism causes lung infection, with faver, cough, and chest pain -found in air, water, and soil and is carried by animals
210
Toxoplasmosis (Toxo)
parasitic infection involving central nervous system - fevers, chills, visual disturbances, confusion hemiperesis, seizures - from uncooked lamb and pork, unpasturized dairy products, raw eggs/ vegetables
211
TB Tuberculosis
Bacterial Disease involving lungs, brain, and other organs | -symptoms are fever cough, loss of weight, anorexia, and blood in sputum
212
Hodkin Lymphoma (Reed-Sternberg Cell)
Tumor of lymphoid tissue, mainly in spleen and lymph nodes | -enlarged lymph nodes
213
Non-Hodkin Lymphoma (Follicular Lymphoma, Large Cell Lymphoma)
- B-cell lymphomas, not T | - Chemotherapy may help cure or stop progress of disease
214
Multiple Myeloma
Malignant tumor of bone marrow cells
215
Thymoma
Malignant tumor of Thymus, associated with myasthenia gravis -patients may have other autoimmune disorders such as lupus erythmatosus and rheumatoid arthritis
216
Kaposi Sarcoma
Malignant lesion associated with AIDS: arises from lining of capillaries and appears as red, purple, brown, or black skin nodules
217
Wasting Syndrome
Weight Loss, decrease in muscular strength, appetite, and mental activity; associated with AIDS
218
Poikilocytosis
Disorder of RBC morphology: RBCS are unusual shape
219
Neutropenia
Decrease of Neutrophils
220
Dyspnea
Difficulty breathing
221
Sideroperia
Iron deficiency
222
dysphagia
difficulty Swallowing
223
Myelodysplasia
- immature blood cells in the bone marrow do not mature and do not become healthy blood cells. (not enough functioning blood cells - Early on no symptoms. Later symptoms feeling tired, shortness of breath, easy bleeding, or frequent infections
224
Melena
dark feces containing partly digested blood
225
Ascities
Abnormal accumulation of abdominal fluid
226
Hemoglobin
Blood protein containing iron; carries oxygen in RBCs
227
4 types of plasma proteins
Albumin, Globulin, fibrinogen, prothrombin
228
Warfarin (Coumadin)
Drug given to patient to prevent formation of clots
229
Anticoagulant
substance that prevents clotting
230
Phagocyte
cell that eats or swallows other cells
231
Myelopoiesis
formation of bone marrow
232
Eosinophilia
Increase in type of white blood cell (seen in allergies)
233
-Pheresis
separation
234
Anemia
Deficiency in number of red blood cells
235
Hypochromic
pertaining to reduction of hemoglobin in red blood cells
236
anisocytosis
Variation in size of red blood cells
237
Spherocytosis
Abnormal numbers of round, rather than normally biconcave-shaped, red blood cells
238
Microcytosis
Increase in number of small red blood cells
239
Blood dyscrasias
disease or disorder related to blood
240
Bence Jones Protein
Immunoglobulin fragment found in urine of patients with multiple myeloma
241
Relapse
Symptoms of the disease's return
242
Remission
Symptoms of the disease's disappearance
243
Ecchymoses
Large blue or purplish patches on skin (bruises)
244
Pancytopenia
Deficiency of all blood cells
245
Petechiae
Tiny purple or red spots on skin occurring as a result of small hemorrhages
246
Packed Cells
Preparation of erythrocytes separated from plasma
247
Graft-Versus-host disease (GVHD)
Immune reaction of donor’s cells/tissue to recipient’s cell/tissue; a possible outcome of hematopoietic stem cell or bone marrow transplantation
248
-philia
denoting undue inclination
249
-phoresis
indicating a transmission, separation
250
Hypersplenism
Syndrome marked by enlargement of spleen and associated with anemia, leukopenia, and thrombocytopenia
251
Allergen
Antigen capable of causing allergy (hypersensitivity)
252
anaphylaxis
Extraordinary hypersensitivity to a foreign protein; marked by hypertension, shock, and respiratory distress