Chapter 13 - Disorders Of RBC's Flashcards
Hemoglobin does what?
Carries Oxygen!
Almost _____% of iron is bound to heme in hemoglobin
80%
Iron is stored as _________ in the _________
Ferritin
Liver
What is ferritin?
Protein-iron complex
What is Spleen also known as and why?
“Garbage can”
- it desposes of everything
What is Erythropoiesis?
The production of RBC’s
What bones are used for RBC production?
Bone Marrow
- after age of 20yrs old
- vertebrae, sternum, rubs, & pelvis
What is Erythropoietin?
Important hormone
- 90% of this hormone is produced by the kidneys
________________ is necessary for stimulation of bone marrow?
Erythropoietin
Most of the heme unit is converted into _____________?
Bilirubin
Unconjugated bilirubin happens when what?
When there is an excessive amount of RBC destruction, leading to jaundice
Bilirubin is stored where?
In the Liver
Random
Unconjucated bilirubin Jaundice
🤓
What is Anemia?
Low red blood cells
Example of rapid blood loss?
Stabbing
The circulatory system shuts down
Example of slow blood loss?
GI bleed
Menstraul period
- the body may loose 50% before signs and symptoms show up
What is Hemolysis?
Break down of blood
What is Sickle Cell Disease?
Mutation in beta chains of hemoglobin
Sickle cell disease causes a lot of what?
A lot of occlusion
What things does sickle cell disease lead to?
- Chronic hemolytic anemia
- Pain- can’t pass through as easily causing pain
- Organ failure
Individuals with a Sickle Cell Disease are at high risk for what?
Multi system organ failure
What is Acidosis?
Body has to many H ions
When are blood transfusions typically administered?
When RBC’s count falls below 7 (<7)
What is the typical order of interventions in the hospital for a sickle cell crisis?
- Always fluids!
- Pain management ( pain WON’T kill)
** Physiological first
Pain second
