Chapter 13 ( Transplantation ) Flashcards Preview

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Flashcards in Chapter 13 ( Transplantation ) Deck (6)
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1
Q

Hyperacute graft rejection timing ? Mechanism ?

A

Within minuets to hours

Due to preformed antibodies due to transfusion , multi-parity or previous organ transplants ( type ll cytotoxic hypersensitivity ) , antibodies bind to the grafted tissue and activate complement and the clotting cascade resulting in thrombosis and ischemic necrosis

2
Q

Acute graft rejection timing and mechanism ?

A

Within days to weeks

Similar to primary immune response
Induced by alloantigens in the graft , both CD4,8 T cells play a role as well as antibodies

3
Q

Daclizumab , Basiliximab mechanism of action ?

A

Blocks T cell proliferation by blocking the binding of IL-2 and by opsonization of IL-2R bearing cells

4
Q

Muromonab mechanism of action ?

A

Blocks T cell activation by causing apoptosis

5
Q

Belatacept mechanism of action ?

A

Inhibits T cell activation by blocking the B7 costimulatory molecule binding to CD28

6
Q

Alemtuzumab mechanism of action ?

A

Depletes pool of T cells by binding to them and causing complement mediated lysis