Chapter 14: The Brain and Cranial Nerves Flashcards

(70 cards)

1
Q

Brain Anatomy: An Overview

A

Half of CNS
* Weight: 1,450 – 1,600 g

Divided into regions
* Forebrain, midbrain, hindbrain
* Cerebrum, diencephalon, cerebellum,
brain stem

  • 12 cranial nerves
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2
Q

Gray and White Matter

A

Gray matter
* Neurosomas, dendrites, synapses
* Forms cortex
* Forms deeper nuclei

White matter
* Bundles of axons
* Forms tracts

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3
Q

Cranial Meninges

A
  • Membranes surrounding brain

Functions
* Protection of brain
* Structural framework for blood vessels

Three meninges
* Dura mater
* Arachnoid mater
* Pia mater

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4
Q

Dura Mater

A

Most superficial
* Potential space

  • Tough, fibrous

Two layers
* Periosteal (superficial)
* Meningeal (deep)

Layers fused except at dural sinuses
* Collect blood from brain

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5
Q

Dural Folds

A
  • Divide brain regions
  • Stabilize and support brain

Falx cerebri
* Separates cerebral hemispheres

Tentorium cerebelli
* Divides cerebrum from cerebellum

Falx cerbelli
* Partially separates cerebellar hemispheres

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6
Q

Arachnoid Mater

A
  • Intermediate
  • Thin, transparent

Subdural space
* Between dura and arachnoid

Subarachnoid space
* Between arachnoid and pia
* Filled with cerebrospinal fluid
* Crossed by arachnoid trabeculae

Arachnoid granulations project into dural sinuses
* Return CSF to blood

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7
Q

Pia Mater

A
  • Deepest
  • Thin, delicate

Conforms to surface anatomy of brain
* Dips into sulci

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8
Q

Ventricle Overview

A
  • Fluid-filled chambers
  • Cerebrospinal fluid

House choroid plexus
* Capillaries + ependymal cells
* Produces cerebrospinal fluid
* Blood-CSF barrier
* Tight junctions between ependymal cells
* Part of brain barrier system

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9
Q

Ventricles

A

Lateral ventricle
* Paired
* Cerebrum
* Connect to third via interventricular foramen

Third ventricle
* Unpaired
* Diencephalon
* Connect to fourth via cerebral aqueduct

Fourth ventricle
* Unpaired
* Between brainstem and cerebellum
* Gives rise to spinal central canal

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10
Q

Cerebrospinal Fluid (CSF)

A
  • Clear, colorless fluid
  • Constantly produced and reabsorbed
  • Fills ventricles, canals, subarachnoid space
  • Bathes external surface

Produced by filtering blood
* Composition different from plasma

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11
Q

Functions of Cerebrospinal Fluid

A

Buoyancy
* Supports weight of brain

Protection
* Cushions brain
* Slows movement within skull

Chemical stability
* Regulates environment of nervous tissue
* Rinses wastes from nervous tissue
* Circulates nutrients and chemicals

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12
Q

Cerebrospinal Fluid Flow

A

Flows due to
* Own pressure
* Ependymal cilia motion
* Pulsation of brain
* Due to heartbeat

  • Flows through ventricles in sequence

Enters subarachnoid space
* Via apertures
* Arachnoid granulations drain excess fluid

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13
Q

Blood Supply to Brain

A

High oxygen and glucose demands
* Requires constant blood flow
* Disruptions cause loss of consciousness or permanent damage

Major arteries
* Internal carotid artery
* Vertebral artery

Major veins
* Internal jugular vein

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14
Q

Blood-Brain Barrier (BBB)

A
  • Part of brain barrier system (BBS)

Formed by:
* Tight junctions between endothelial cells of capillaries
* Basement membrane endothelial cells
* Perivascular feet of astrocytes

Prevents entry of harmful or disruptive substances
* Transport is selective, directional

Absent or reduced in some areas
* Circumventricular organs (CVOs) in 3rd and 4th ventricles
* Needed to monitor blood composition

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15
Q

What Can Cross the BBS?

A

Highly permeable
* Glucose, water
* Lipid-soluble materials
* Respiratory gases
* Alcohol, nicotine, caffeine, anesthetics

Somewhat permeable
* Na+, K+, Cl-, urea, creatinine

Impermeable
* Proteins, formed elements, most antibiotics, cancer drugs

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16
Q

Brainstem Overview

A
  • Connects brain to spinal cord
  • Houses majority of cranial nerve nuclei

Divided into three regions
* Midbrain
* Pons
* Medulla oblongata

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17
Q

Medulla Oblongata

A
  • Most inferior region

Wider compared to spinal cord
* Distinctive anatomical features

Houses ascending and descending tracts
* Connect brain to spinal cord

Houses cranial nerve nuclei
* Nerves VIII (partial) – XII

  • Houses portions of reticular formation
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18
Q

Medulla Oblongata: Notable Structures

A

Pyramids
* Anterior
* Houses corticospinal tracts

Gracile and cuneate nuclei
* Axons form medial lemniscus

Olives
* Lateral to pyramids
* Contain olivary nuclei

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19
Q

Medulla Oblongata: Pathways

A

Corticospinal tracts
* Descending (motor) tracts
* Carry signals from cerebral cortex to skeletal muscles
* Tracts decussate

Medial lemniscus
* Ascending (sensory) pathway
* Carries general sensory information
* Synapse with thalamus
* Decussate

Inferior olivary nuclei
* Relay between other CNS structures and cerebellum

Tectospinal tract
* Controls neck muscle

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20
Q

Medulla Oblongata: Neural
Networks

A

Sensory Functions
* Hearing
* Touch
* Temperature
* Pressure
* Taste
* Pain

Motor Functions
* Chewing
* Salivation
* Swallowing
* Gagging
* Vomiting
* Speech
* Coughing
* Sneezing
* Sweating
* Respiration
* Cardiovascular control
* Gastrointestinal control
* Movements of head, neck, shoulders

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21
Q

Medulla Oblongata: Centers

A

Cardiac center
* Regulation of force and rate of contraction

Vasomotor center
* Regulation of blood vessel diameter

Respiratory centers
* Regulates rhythm and depth of breathing

  • Other centers (vomiting, swallowing, etc.)
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22
Q

Pons

A

Middle region of brainstem
* Separated from medulla by groove

Houses cranial nerve nuclei
* V – VIII (partial)

Houses continuations of tracts
* Ascending and descending

  • Houses portions of reticular formation
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23
Q

Pons: Notable Structures

A

Middle cerebellar peduncles
* Posterior
* Connect pons and midbrain to cerebellum

Portion of fourth ventricle
* Lies between pons and cerebellum

White matter tracts (fascicles)
* Longitudinal projection tracts send signals up and down brainstem
* Transverse tracts connect left and right cerebellar hemispheres

Pontine respiratory center
* Alters rhythm of breathing

Other reticular formation nuclei
* Sleep, posture

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24
Q

Midbrain

A
  • Most superior region

Connects brainstem to diencephalon
* Hindbrain to forebrain

Houses continuations of tracts
* Ascending and descending

Houses cranial nerve nuclei
* III and IV

  • Houses portions of reticular formation
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25
Notable Structures of the Midbrain
Cerebral aqueduct * Surrounded by central gray substance * Role in pain awareness Tectum * Posterior to cerebral aqueduct * Superior and inferior colliculi * Visual and auditory reflexes Cerebral peduncles * Anterior to cerebral aqueduct * Anchor cerebrum to brainstem * Divided into three regions
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Midbrain: Cerebral Peduncle Divisions
Tegmentum * Houses red nucleus * Tracts connect to cerebellum * Participate in fine motor control Substantia nigra * Motor center * Inhibits thalamus and basal nuclei * Suppress unwanted movement Cerebral crus * Connect cerebrum to pons * House corticospinal tracts
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Midbrain: Superior and Inferior Colliculi
Superior colliculi * Control extrinsic eye muscle * Direct gaze * Track moving objects * Move eyes and head due to visual stimuli * Connected to other visual control nuclei Inferior colliculi * Relays information from inner ear to thalamus and other brain regions * Sensitive to time delays between sounds between ears (sound location) * Process pitch fluctuations * Turn head in reflexive responses to sound * Startle reflex to noise
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The Reticular Formation
Network of grey matter * Housed between tracts and distinct nuclei * > 100 neural networks * Passes through all regions of brainstem and upper spinal cord * Connections to cerebrum Networks have numerous functions * Sensory and motor
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Reticular Formation Functions: Somatic Motor Control
Motor cortex neurons synapse with reticular formation nuclei * Form reticulospinal tracts: alter muscle tension * Balance, posture, muscle tone Relays sensory signals to cerebellum * Visual, auditory, vestibular * Required for cerebellum’s role as motor coordinator * Gaze centers allow eyes to track motion and fix on objects Central pattern generators produce rhythmic signals * Breathing and swallowing
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Reticular Formation Functions
Cardiovascular control * Via cardiac and vasomotor centers * Alters cardiac output and blood pressure Pain modulation * Route for pain signals from lower body to cerebral cortex * Descending analgesic tracts can block pain sensation Sleep and consciousness * Reticular activating system (RAS) * Level of control over which sensations reach cerebrum * Role in stages of consciousness: alertness, sleep * Damage can lead to permanent coma Habituation * Reticular activating system (RAS) * Brain ignores unimportant, repetitive stimuli * Novel or important stimuli are still attended too
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Cerebellum Overview
Second largest region of brain * 10% of brain’s mass * 50% of brain’s neurons * Component of hindbrain * Numerous granule cell neurons Distinctive Purkinje cells * Highly branched dendrites in single plane
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Cerebellar Anatomy
Divided into hemispheres * Connected by vermis * Covered by folia separated by sulci Each hemisphere divided into lobes * Anterior and posterior * Divided by primary fissure Grey matter * Cerebellar cortex: receives input * Deep nuclei: handles output White matter * Arbor vitae
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Cerebellar Peduncles
* Connect cerebellum to brainstem * Contain bundles of nerve fibers Superior: midbrain * Output from cerebellum Middle: pons * Input from rest of brain Inferior: medulla oblongata * Input from spine
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Cerebellar Functions
* Region is still poorly understood * General function appears to be evaluation of sensory input Cerebellar lesions affect a number of functions * Sensory, motor, linguistic, emotional, other nonmotor functions Possible involvement with: * Tactile sensation * Spatial perception * Timekeeping * Predicting path of moving object * Hearing * Language output * Planning/scheduling * Emotion and impulse control
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Cerebellum: Motor Functions
* Important for motor coordination * Aids in learning motor skills * Maintain muscle tone and posture * Smooths muscle contractions * Coordinates eye and body movements * Coordinates motion of different joints
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Cerebellum as Motor Comparator
Receives information from * Cerebrum * Eyes and inner ears * Proprioceptors in joints and muscles Cerebrum initiates movement * Sends “plan” to cerebellum Cerebellum compares “plan” to actual movements * Via Purkinje cells Errors stimulate deep nuclei * Send information to thalamus and brainstem * Information sent to motor association area * Information sent to reticulospinal and vestibulospinal tracts * Error corrected
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Diencephalon Overview
Inferior to cerebrum * Deep to cerebral hemispheres * Component of forebrain * Superior to brainstem Divided into * Epithalamus * Thalamus * Hypothalamus
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Thalamus Structure
Paired, oval masses * Joined by interthalamic adhesion (medial) * 4/5ths of diencephalon * Laterally: protrude into lateral ventricles * Medially: protrude into third ventricle Composed of 23 nuclei * Divided into five groups
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Thalamus Functions
Sensation * Ascending sensory neurons synapse with thalamic nuclei * General and special senses * Thalamus processes information * Some information sent on to cerebrum * Information sent to corresponding cortical region Motor control * Relays signals from cerebellum to cerebrum * Feedback loops between cerebral cortex and basal nuclei Memory and emotion * Nuclei associated with limbic system
40
Hypothalamus Structure
* Inferior and anterior to thalamus Runs from optic chiasm to mammillary bodies * Mammillary nuclei relay limbic signals to thalamus * Makes up walls and floor of third ventricle * Pituitary gland attached via infundibulum * Divided into nuclei
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Hypothalamus Functions
Hormone secretion * Produces oxytocin and antidiuretic hormone * Produces regulatory hormones which control anterior pituitary gland * Influence on metabolism, growth, stress response, reproduction Autonomic effects * Integrating center for the autonomic nervous system * Sends descending fibers to brainstem * Influence heart rate, blood pressure, GI tract secretion and motility, etc. Thermoregulation * Integrating (control) center for negative feedback loop * Monitors body temperature * Activates mechanisms to control temperature Regulation of food intake * Monitors blood nutrient level * Receptors for hormones that influence hunger and satiety * Receptors for hormones that influence body mass Regulation of water intake * Osmoreceptors monitor concentration of blood * Promotes thirst and drinking * Release of ADH Sleep and circadian rhythms * Part of reticular formation * Nuclei regulate sleep/waking rhythms * Controls 24-hour circadian rhythm Memory * Mammillary nuclei lie in pathway between hippocampus and thalamus * Lesions cause memory defects Emotional behavior and sexual response * Centers for anger, fear, aggression, contentment, pleasure * Centers for sexual drive, copulation, orgasm
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Epithalamus
Smallest portion of diencephalon * Posterior * Forms roof of third ventricle Contains pineal gland * Produces melatonin * Possible role in circadian rhythms * Possible role in mood and sexual maturation Contains habenula * Relays signals from limbic system to midbrain * Connects limbic system to rest of brain
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Cerebrum Overview
Largest region of brain * Encompasses diencephalon * Component of forebrain Extensively folded compared to other animals * Increases surface area
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Cerebral Anatomy
Two hemispheres * Divided by longitudinal cerebral fissure * Connected by corpus callsoum * Separated from cerebellum via transverse cerebral fissure Divided into five lobes * Divided by sulci Surface covered by raised gyri * Divided by sulci
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Lobes and Sulci
Frontal lobe * Most anterior/rostral * Runs to central sulcus Parietal lobe * Most superior lobe of brain * Begins at central sulcus * Extends to parieto-occipital sulcus Occipital lobe * Most posterior/caudal * Begins at parieto-occipital sulcus Temporal lobe * Lateral, horizontal * Separated from parietal lobe by lateral sulcus Insula * Deep to other lobes * Deep to lateral sulcus
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Cerebral Gray and White Matter
White Matter * Permits communication between different regions * Majority of cerebral volume * Divided into tracts Gray Matter * Responsible for neural integration * Three locations * Cerebral cortex * Basal nuclei * Limbic system
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Cerebral White Matter
Association tracts * Connect regions within a hemisphere * Short fibers: gyri within lobe * Long fibers: lobes within hemisphere Commissural tracts * Connect hemispheres through commissures * Most pass through corpus callosum Projection tracts * Connect cerebrum with rest of body * Ascending and descending
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Cerebral Cortex
* Gray matter * Lines outer cerebrum * Thin (2 - 3 mm) * 40% of brain’s mass Complex anatomy * Divided into layered regions * Specialized neurons * Stellate cells and pyramidal cells
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Basal Nuclei
Gray matter * Lateral to thalamus * Paired in each hemisphere Receive input from * Cerebral cortex * Substantia nigra (inhibitory) Send output to * Thalamus * Relays signals to cerebral cortex and midbrain Confirmed structures * Caudate nucleus * Putamen * Globus pallidus
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Basal Nuclei and Motor Control
* Determine onset and cessation of voluntary movements * Rhythmic, repetitive movements of hips and shoulders during walking Highly practiced, learned motor behaviors * Typing a shoe , writing, etc. Lesions cause dyskinesias * Movement disorders * Note: these are only some selected functions in motor control
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Limbic System
* Gray matter Structures found in a ring * Around corpus callosum and thalamus All components are paired * Present in both hemispheres * Emotion and learning
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Components of the Limbic System
Structures interconnected via fiber tracts * Permits feedback between components Confirmed structures * Cingulate gyrus * Hippocampus * Amygdala Other components * Mammillary bodies * Some hypothalamic nuclei * Some thalamic nuclei * Basal nuclei (portions) * Prefrontal and orbitofrontal cortex
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Limbic System Functions
Roles in emotion * Amygdala and hypothalamus * Emotions originate here * Amygdala can link sensations to emotional responses * Output to hypothalamus and brainstem: alters motor responses * Output to prefrontal cortex: permits conscious expression of emotions Memory * Hippocampus Houses gratification and aversion centers * Linked to stimuli * Roles in shaping behavior * More likely to repeat pleasurable experiences * Less likely to repeat unpleasant experiences
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Functions of the Cerebrum
Difficult to correlate specific function with a specific region * Boundaries are indistinct, overlap exists * Areas may have multiple functions * Functions may be distributed (over many areas) * Typically divided into functional areas
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Cerebral Lateralization
Due to tracts decussating * Receive information from opposite side of body * Control effectors on opposite side of body Hemispheres specialized for some different functions * Cerebral (hemispheric) lateralization * Functions may complement one another Typically both hemispheres are used for all tasks * Communicate via commissural tracts Left Hemisphere (Usually) * Categorical hemisphere * Break info into fragments * Linear analysis of info * Spoken and written language * Sequential and analytic reasoning * Posterior language area * Motor speech area Right Hemisphere (Usually) * Representational hemisphere * Integrated, holistic perception of info * Imagination and insight * Artistic and musical skill * Perception of patterns and spatial relationships * Sensory comparison * Affective language area
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Cerebral Cortex: Functional Areas
Sensory areas * Primary sensory cortex * First receive sensory information * Permits conscious awareness of sensation Motor areas * Primary motor cortex * Voluntary control of skeletal muscle Association areas * Interpret information * Involved with cognition * Range of mental processes by which knowledge is acquired and used
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Primary Somatosensory Cortex
Postcentral gyrus * Parietal lobe Demonstrates somatopy * Body regions correspond to specific brain regions * Permits spatial discrimination of stimuli More cortex dedicated to some areas * Corresponds to sensitivity * Sensory homunculus Function * Conscious perception of general senses
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Sensory Cortices of Special Senses
Primary visual * Posterior occipital lobe Primary auditory * Superior temporal lobe and insula Primary gustatory * Inferior postcentral gyrus Primary olfactory * Medial temporal lobe, inferior surface of frontal lobe
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Primary Motor Area
Precentral gyrus * Frontal lobe * Demonstrates somatopy More cortex dedicated to some areas * Corresponds to motor control * Number of muscles and motor units * Motor homunculus Function * Voluntary control of skeletal muscle
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Sensory Association Areas
* Always located close to primary sensory cortex for sensation * Integrates and interpret sensory information * Store memories
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Motor Association (Premotor) Area
* Frontal lobe, anterior to precentral gyrus Plans motor movements * Degree and sequence of contractions * Plan transferred to primary motor area for execution
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Language Association Areas
Posterior language area (Wernicke) * Posterior to lateral sulcus * Receives input from visual, auditory, and somatosensory areas * Recognition of written and spoken language * Formulates speech, transmits to motor speech area * Damage: fluent aphasia Motor speech area (Broca) * Inferior prefrontal cortex * Receives plan for speech from posterior language area * Creates motor plan for speech, sends to primary motor area * Possible roles in language comprehension * Damage: nonfluent aphasia
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Affective Language Area
Area opposite posterior language area * Recognizes emotional context of another’s speech * Damage impedes this ability Area opposite motor speech area * Add emotional content to spoken words * Damage results in aprosody (flat, emotionless speech)
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Frontal Association Area (Prefrontal Area)
* Anterior portion of frontal lobe Frontal lobe integrates information * From sensory and motor regions * From other association area Associated with cognition and higher functions * Judgement, planning, decision making, conscience, reasoning, mood, etc. * Conscious control of emotional expression * Damage personality disorders, loss of inhibition, inability to control expression of emotions
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Memory
* Storage and recall of information Neural level: * Relies upon formation and modification of synapses * Memory trace (engram): pathway of synapses associated with memory * Synaptic plasticity: synapse added, removed, modified * Synaptic potentiation: transmission becomes easier with repetition and learning Involves multiple processes * Learning: acquiring new information * Memory proper: storage and retrieval * Forgetting: eliminating unwanted or trivial information
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Three Categories of Memory
Immediate memory: what just happened * Duration: seconds * Comprehension of flow of events Short term-memory (STM) * Duration: seconds to hours * Small information capacity * Can be forgotten quickly * Recitation allows better retention Long-term memory (LTM) * Duration: years to a lifetime * Large information capacity * Modification of synapses or adding more NT channels
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Structures Involved in Memory
Hippocampus transfers memories from STM to LTM * Referred to as memory consolidation * Does not store memory! Long term memories stored in cerebral cortex * Within appropriate region Other regions associated with memory * Cerebellum: learning motor skills * Amygdala: emotional memory
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Memory Defects
Anterograde amnesia * Inability to form new memories * Can result from hippocampus damage Retrograde amnesia * Inability to recall stored LTM
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Cranial Nerve Overview
* 12 pairs Numbered from I – XII * Anterior (rostral) to posterior (caudal) * Peripheral nervous system Associated primarily with structures of the head and neck * Vagus nerve is a notable exception * Sensory, motor, or mixed (both)
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Cranial Nerves
Olfactory Nerve I (S) * Olfaction Optic Nerve II (S) * Vision Oculomotor Nerve III (M) * Somatic and autonomic motor functions of eye * Innervates four of six eye muscles Trochlear Nerve IV (M) * Eye movements * Innervates one eye muscle Trigeminal Nerve V (B) * Three branches * Sensory: general senses of face * Motor: mastication Abducens Nerve VI (M) * Eye movements * Innervates one eye muscle Facial Nerve VII (B) * Sensory: taste * Motor: facial expressions, secretion from salivary and lacrimal glands Vestibulocochlear Nerve VIII (S) * Hearing and equilibrium Glossopharyngeal Nerve IX (B) * Sensation (taste, general senses) from tongue, throat, outer ear * Muscles of tongue and pharynx, salivary glands * Chemoreceptors and baroreceptors in cardiovascular system Vagus Nerve X (B) * Control of cardiac, pulmonary, digestive, urinary functions * Parasympathetic division Accessory Nerve XI (M) * Swallowing, movement of neck and shoulder muscles Hypoglossal Nerve XII (M) * Movements of tongue