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Chapter 15 Flashcards

(14 cards)

1
Q

Salvage recovery

A

Biosynthetic pathway that uses or recycles intermediates from the corresponding degradative pathway.

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2
Q

5-Phophoribosyl-1-pyrophosphate (PRPP)

A

supplies ribose phosphate in the synthesis of purines and pyrimidines

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3
Q

Nucleoside Monophosphate Kinase

A

Enzyme catalyzing the transfer of a terminal phosphate group from ATP to a nucleoside monophosphate

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4
Q

Nucleoside Diphosphate Kinase

A

Enzyme catalyzing the transfer of a terminal phosphate group from a nucleoside triphosphate to a nucleoside diphosphate

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5
Q

Ribonucleotide Reductase

A

Enzyme that converts ribonucleotide diphosphate to deoxyribonucleotide diphosphate, with concomitant oxidation of NADPH to NADP+.

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6
Q

Thimidylate Synthase

A

Enzyme that methylates deoxyuridylate to form deoxythymidylate

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7
Q

5-Flourouricil

A

an analog of uracil; activated in the body to give 5-fluoro-deoxyuridylate(F-dUMP), a suicide substrate for thymidylate synthase.

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8
Q

Gout

A

a disease of the joints caused by high serum levels of uric acid(urate)

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9
Q

Lesch-Nyhan Syndrome

A

A rare inheritable disorder that is due to a lack of activity of the enzyme hypoxanthine-guanine phosphoribosyl transferase

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10
Q

Hypoxanthine

A

6-Hydroxypurine

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11
Q

Inosine

A

Purine nucleoside in which the base is hypoxanthine

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12
Q

Hypoxanthine-Guanine Phosphoribosyl Transferase

A

Enzyme involved in the purine salvage pathway; a lack of this enzyme leads to Lesch-Nyhan syndrome

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13
Q

Urate/ Uric Acid

A

2,6,8-Trihydroxypurine, or 7,9-dihydro-1H-purine-2,6,8(3H)-trione

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14
Q

Xanthine Oxidase

A

enzyme which catalyzes oxidation of hypoxanthine to xanthine, and xanthine to uric acid

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