Chapter 15 Antiparkinson Drugs

Question 1

Parkinson Disease and know all the drug class and examples (look at class activities as 
well).

Treatment and mechanism of action of Alzheimer’s and Myasthenia gravis drugs.

Please read pathophysiology on different neurodegenerative diseases.

Answer 1

study guide

Question 2

Parkinson Disease?

Answer 2

chronic, progressive degenerative disorder imbalance of dopamine and AcH

Question 3

Parkinson’s Disease S/S

Answer 3

Tremor
Rigidity
Akinesia
Postural instability

Drooling/gait

Question 4

Dyskinesia?

Answer 4

difficulty in performing voluntary movements

Question 5

Pharmacology Treatment of parkinson Disease Monoamine oxidase inhibitor

2. Drug?
3. dosage
4. contraindication

Answer 5

2. Selegiline, Rasagiline
   3, selegiline 10mg or less
3. meperidine

Question 6

Dopamine Modulator

1. Drugs
2. adverse effects:
3. Interaction:
4. effective length

Answer 6

amantadine

2. dizzy, insomnia, nausea
3. anticholinergic effecs increase
4. 6-12 months

Question 7

CoxT
Drugs
2. what does it do to wearing off phenomenon of levodopa?
3. adverse effects

Answer 7

(PONE)
Tolcapone, entacapone
2. reduce it
3. gi upset, urine discoloration, can worsen dyskinesia that may already be present.

Question 8

Direct acting dopamine receptor agaonist

1. Ergot
2. action:
3. Used with?
4. adverse effects:
5. nonergot

Answer 8

1. bromocriptine (bromo)
   action: inhibits lactation
   Used with carbidopa levodopa so that lower levodopa are needed
2. gi upset, dyskinesias, sleep disturbance
3. Ropinirole, rotigotine (RO prefix)