Chapter 16: Head & Neck (Dobson) Flashcards
(9 cards)
What were inflammatory reactive lesions discussed & what is their distinguishing features
Apthous ulcers - Canker ssores
Traumatic fibroma - Buccal mucosa lesions from repetitive trauma
Pyogenic granuloma - pregnancy tumor
Peripheral ossifying fibroma - red, ulcerated and/or nodular typically in young teenage females
What test is used to diagnose HSV oral infection
Tzank Test
Presence of intranuclear viral inclusions or multinucleate polykaryons on a smear
What is the primary cause of SCC of the oropharynx
Infection with high-risk human papillomavirus (HPV)
What is the pathogenesis of HPV induced oropharyngeal SCC
- Activity of viral genes E6 & E7 leading to inactivation of p53 and RB pathway
- p16 overexpression (p16 is encoded by CDKN2A)
What were the benign tumors of the salivary glands discussed
Pleomorphic Adenoma
Warthin tumor
What is the pathogenesis of pleomorphic adenomas
Overexpression of PLAG1 or mutations of HMGA2 gene
What malignant salivary gland tumors were discussed
Mucoepidermoid carcinoma
Adenoid cystic carcinoma
What is the pathogenesis of more than half of mucoepidermoid cases
(11;19)(q21;p13) translocation = CRTC1-MAML2 fusion protein
What gene rearrangement is present in a subset of adenoic cystic carcinomas
MYB-NFIB
