Chapter 18- Populations and Evolution Flashcards
3.7.2, 3.7.3 (81 cards)
What is a population?
- Group of organisms of the same species that occupies a particular space at a particular time and can potentially interbreed.
- There is variation in the phenotypes of organisms in a population, due to genetic and environmental factors.
What is a species?
- Group of similar organisms that can reproduce to give fertile offspring.
- Exist as one or more populations.
What is a gene pool?
All the alleles of all the genes of all individuals in a particular population at a given time.
What is allele frequency?
The number of times an allele occurs within the gene pool- usually given as a percentage or decimal of the total population.
How does allele frequency vary?
- Allele frequency- affected by selection- due to environmental factors.
- Unless an allele leads to a phenotype with an advantage or disadvantage compared with other phenotypes- allele frequency in the population will stay the same from one generation to the next.
How are recessive alleles maintained in a population.
Heterozygous individuals act as a store of recessive alleles in the population, despite not expressing the allele in their phenotype.
Using the example of cystic fibrosis, explain how allele frequencies work.
Probably not going to come up.
- Dominant allele- F- normal mucus production.
- Recessive allele- f- production of thicker mucus.
- Individual humans have two alleles in every cell- one in each of the pair of homologous chromosomes the gene is in.
- Alleles- the same in every person- only count one pair of alleles per gene per individual when considering a gene pool.
- 10,000 people in a population- twice as many- 20,000 alleles in the gene pool of the gene.
- Three different combinations- homozygous dominant- FF, homozygous recessive- ff, heterozygous- Ff.
- Allele frequencies- need to realise heterozygous combination could be written as Ff or fF- conventional to put the dominant allele first.
- Population of 10,000 people- if all 10,000 had genotype FF:
o Probability of anyone being FF would be 1.0 and probability of anyone being ff would be 0..
o Frequency of the F allele- 100%, frequency of the f allele- 0%. - Population was all heterozygous:
o Probability of anyone being Ff would be 1.0.
o Frequency of the F allele 50%.
o Frequency of the f allele 50%.
What does working out the allele frequency of populations with mixed genotypes require?
The Hardy Weinberg principle.
What is the Hardy-Weinberg principle?
- Hardy-Weinberg principle- mathematical model to predict allele frequencies of a particular gene in a population, alongside genotype and phenotype frequencies.
- Predicts that allele frequencies will not change from generation to generation. Assumption that the proportion of dominant and recessive alleles of any gene in a population remains the same from one generation to the next.
When does the Hardy-Weinberg principle apply?
- No mutations occur.
- The population is isolated- no flow of alleles in/out of the population- no immigration, or emigration.
- No natural selection- alleles are equally likely to be passed to the next generation.
- Population is large.
- Mating within the population is random- all possible genotypes can breed with each other.
- Unlikely the conditions are met but the Hardy-Weinberg principle still useful in studying gene frequencies.
How can the Hardy-Weinberg equation be used?
- You may be asked about collecting data about the frequency of observable phenotypes within a single population.
- You could be asked to calculate allele, genotype and phenotype frequencies in a population from appropriate data using the Hardy–Weinberg equation.
- Use the equations to determine the probability of any allele in a population.
- Hardy-Weinberg equations can also be used to test whether the Hardy-Weinberg principle applies to alleles in a population- to test whether selection or other factors are influencing the allele frequencies.
- If frequencies change between generations in a large population- something is influencing the population.
When are the Hardy-Weinberg equations in the spec used?
When a gene has two alleles.
What are the values used in the Hardy-Weinberg equation?
- p and q can be randomly assigned to alleles, but it is usually assigned as follows:
- p= frequency of dominant allele A.
- q= frequency of recessive allele a.
What is the allele frequency Hardy-Weinberg equation and how is it derived?
- There are only two alleles.
- The total frequency of all the possible alleles for a characteristic in a certain population is 1.0, so the combined frequencies of the two alleles must be 1.
- p+q= 1.
What is the genotype frequency equation for the Hardy-Weinberg equation and how is it derived?
- Total frequency of all possible genotypes for one characteristic in a certain population is 1.0.
- There are only 4 possible genotypes for 2 alleles- the frequencies of individual genotypes must add to 1.0.
- AA+ Aa+ aA+ aa= 1
- p2+2pq+q2= 1
- p2= homozygous dominant genotype
- 2pq= heterozygous genotype (carriers).
- q2 = homozygous recessive genotype.
- Remember to label which one is which to ensure marks.
How do you work out genotype/ phenotype frequencies using the Hardy-Weinberg principle.
- Genotype- alleles an organism has.
- Phenotype- expression of the genotype in the environment.
- The genotype frequencies can be used to work out phenotype frequencies if you know how the genotype relates to the phenotype.
Other than monohybrid crosses, what other situations can the Hardy-Weinberg equations work in.
Work if two alleles are codominant or if you don’t know which allele is recessive and which is dominant- in these cases p represents one allele and q represents another- random allocation but need to be consistent with the use of each letter.
Look at notes for examples of using the Hardy-Weinberg equations in calculations.
Answer on revision card.
How do you use the Hardy-Weinberg principle to show if external factors are affecting the allele frequency.
- Hardy- Weinberg principle- predicts frequencies of alleles in a population don’t change form one generation to the next as long as the population is larger, there is no immigration, emigration, mutations or natural selection and mating is totally random.
- Hardy- Weinberg equations- can show allele frequency changed from one generation to the next- principle doesn’t apply to the population so a factor must be affecting the allele frequency.
What is variation?
- Variation- differences that exist between individuals.
- Intraspecific variation- variation within a species.
- Individuals within a population of a species may show a wide range of variation in phenotype- need to be able to explain why.
What is variation caused by?
- Variation- mostly caused by a combination of genetic and environmental factors affecting the phenotypes of organisms in a population.
- Two forces affect genetic variation in populations: genetic drift and natural selection.
What causes genetic variation?
- Individuals of the same species have the same genes but different alleles- which cause genetic variation.
- Differences in alleles occur in living individuals but change in each generation.
- Primary source of genetic variation- mutation- changes in the DNA base sequence lead to the formation of new alleles.
- Further genetic variation is caused by meiosis and random fertilisation of gametes during sexual reproduction.
Describe the sources of genetic variation in detail.
- Mutation- changes to genes (through changes in the DNA base sequence leading to new alleles) and chromosomes passed onto the next generation- main source of variation.
- Meiosis- crossing over of chromatids and independent segregation of homologous chromosomes- produces new combinations of alleles before they are passed into the gametes which are all genetically different.
- Random fusion of gametes- sexual reproduction- new combinations of alleles and offspring different from parents- gametes fusing at fertilisation is random- adds variety of offspring parents produce.
What happens if variation is largely caused by genetic factors.
- If variation is caused largely by genetic factors organisms fit into a few distinct forms but there are no intermediate types- characters are controlled by a single gene- discrete.
- E.g. ABO- A, B, AB, O= controlled by a single gene.
- Variation largely due to genetic factors- represented graphically as discrete- bar chart/ pie graph.
- Environmental factors have little influence on these types of factors e.g. blood types.