Chapter 2: Innate Immunity

Question 1

Macrophage function

Answer 1

(1) Phagocytosis, (2) Inflammation

Question 2

IL-1β and TNF-α

Question 3

IL-6

Question 4

CXCL8

Question 5

IL-12

Question 6

Inflammasome

Answer 6

complex of innate cytosolic receptors of NOD-like receptor proteins

Question 7

Neutrophil function

Question 8

Extravasation

Question 9

Extravasation steps

Question 11

Type-1 Interferons IFN-α and IFN-β

Question 12

Dendritic cell specific fx(s)

Answer 12

(1) Phagocytose pathogens and transport to lymph nodes
(2) Process and present pathogen protein fragments to T cells
(3) Pattern recognition receptors elicit production of cytokines to direct appropriate adaptive immune response

Question 13

Dendritic cell general fx

Answer 13

Links innate and adaptive immune systems

Question 14

Systemic infection

Question 15

Malfunctions in TLR signaling

Answer 15

Failure of TLR signaling –> lack of cytokine production –> inadequate innate immune response –> more susceptible to infection

Question 16

Malfunction of macrophage fx

Question 17

Malfunction of neutrophil fx

Question 18

Malfunction of NK cells