chapter 24 anthelminthics

Question 1

pharmacodynamics of anthelminthics

Answer 1

• mebendazole, pyrantel, thiabendazole: treat intestinal nematodes
• mebendazole, thiabendazole, albendazole, ivermectin: tissue nemotodes
• ADRs: n/v/d, abd pn, transient neutropenia, mazzotti reaction (rash within 2-24 hours of po dose) with ivermectin

Question 2

antelmintics

Answer 2

• treats parasitic worms
• 4 types of worms: intestinal nematodes (roundworms), tissue nematodes (roundworms), cestodes (flatworms and tapeworms), trematodes (flukes)
• pin worm most common in US

Question 3

clinical use of anthelminthics

Answer 3

pinworm: single does of mebendazole, pyrantel pamaole or albendazole
whipworm: pyrnatel pamaole, albendazole, mebendazole
roundworm: mebendazole
hookworm: pyrantel pamaole, albendazole, mebendazole
threadworm: ivermectin, thiabendazole
scabies: off label ivermectin

Question 4

monitoring of anthelmethics

Answer 4

-assess for eradication of helminth
-pre and post treatment stool samply
-albendazole and mebendazole given with high fat meal
ivermectin taken on empty stomach
albendazole should not be given to pregnant women and back up contraceptive needed for 1 month after treatment