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CHEM 431C - Biochemistry III > Chapter 26 - DNA Repair > Flashcards

Chapter 26 - DNA Repair Flashcards

(16 cards)

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1
Q

Direct Repair

A

Direct repair of damaged bases. (Photoactivation, O6-alkylguanine transferase)

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2
Q

Photoreactivating enzyme (DNA Photolyase)

A

Repairs cyclobutane (thymine dimers)

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3
Q

What enzyme is responsible for fixing alkylated guanine residues?

A

O6 Alkylguanine transferase

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4
Q

Nucleotide Excision Repair

A

Removes segment of damaged nucleotides, replaces it with new strand.

uvr A, uvr B, uvr C, helicase II (uvr D), DNA pol I, DNA ligase

  • transcription coupled repair
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5
Q

Base Excision Repair

A

Removes BASES of damaged nucleotides, replaces the damaged nucleotides with new strand.

Uracil Replacement: Uracil-DNA-N-Glycolyase, Apyrimidinic Endonuclease, DNA pol I, DNA ligase

Oxidative repair: MutM, MutY, MutT

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6
Q

Mismatch Repair

A

MutS, MutH (methylation dependent), MutL, Exonuclease, Helicase II (MutU), DNA pol III, DNA ligase

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7
Q

Homologous recombination

A
  • Requires DNA homology
  • Holliday junction, single nick (Meselson)
  • RecA, Rec BCD (3’ degradation)
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8
Q

Sequence Specific Recombination

A

Recombination at specific sequences, directed by specific DNA-protein interactions.

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9
Q

Transposons

A

Transposable genetic elements, genes that can move from place to place

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10
Q

Transposons

A

Transposable genetic elements, genes that can move from place to place

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11
Q

Error-prone Repair

A

dinB —> DNA pol IV

umuC, umuD –> DNA pol V

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12
Q

Daughter-strand repair

A

Doesn’t repair damage, but allows replication to continue.
RecA, F, O, R
Ruv A, B, C
DNA polymerase, DNA lygase

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13
Q

What kinds of pyrimidine-pyrimidine dimers/photoproducts are there?

A

(1) Thymine dimers

(2) 6-4 photoproduct

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14
Q

What kinds of pyrimidine-pyrimidine dimers/photoproducts are there?

A

(1) Thymine dimers

(2) 6-4 photoproduct

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15
Q

O6-methylguanine binds to ___?

A

Thymine

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16
Q

8-oxoguanine binds to ___?

CHEM 431C - Biochemistry III (6 decks)

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