Chapter 27 : Macrolides, Oxazidonones, Lincosamides, Glycopeptides, And Lipopetides Flashcards
(27 cards)
What are the 3 most common macrolides?
Erythromycin
Azithromycin ( Z pack )
Clarithromycin
What does macrolides treat? (5)
Whooping cough
Mycoplasma
Gonorrhea
Chlamydia
Ulcers
What’s super important to note about macrolides?
It’s highly protein bound !!
Metabolized in the liver
Macrolides interacts with?(3)
Warfarin
Antifungals
Anticonvulsants
Clarithromycin and erythromycin cause what? (2) it’s super worrisome
Increase risk of muscle toxicity with statin use
Increase fetal dysrthymia when used with drug prolong QT interval
Are there any contradictions for macrolides?
No other than allergies
When two drugs have interactions together does it mean contraindications?
Nope unless stated, but you got to be careful
Erythromycin causes
Azithromycin is a what
Clairthromycin causes
GI upset often
5 day treatment for better long time
( long half life )
Bad taste in the mouth
( metallic taste )
Notes
Side effects
Gi upset
Hepatotoxicity if given with other
Hepatotoxic drugs dysthymia’s
Macromides antibiotics increase risk of ____ with statins
Rhabdomyolysis
Notes
Azithromycin levels may be reduced by antacids
Erythromycin should not be given with other Macrolides cause of its high protein bound
Macrolides have what type of concern?
Liver or kidney?
And why?
Liver
Because it’s excreted through bilirubin & feces
What is the function of oxazolidinones?
Sepsis, mrsa, severe respiratory & skin infections
What are side effects of oxazolidinones? (3)!!!
Think of the O!!
Rhabdomyolysis- statin
Tongue & tooth discoloration
Serotonin syndrome
What is lincosamides ( clindamycin )? Used for?
Treatment for acne
( topical and po )
MRSA
Bone infections
Side effects of Lincosamides (3) ( clindamycin )
Think of the D in this medication
Statins - rhabdomyolysis
Warfarin - bleeding
HIGH RISK FOR CDIFF!!!!!!
Why can’t we give clindamycin and lincomycin with aminophylline, phenytoin, barbiturate and ampicillin?
Drug interactions
What’s the usage of glycopeptides (vancomycin)?
What about the oral version?
MRSA
CDIFF TREATMENT!!
Glycopeptides needs monitoring for drug admistertion why?
Small theruptuc window
Peak and trough monitor
IV Vancomycin reaction causes ?
THIS IS NOT AN ALLERGIC REACTION! ITS A TOXIC
ITS TOO QUICKLY!!!
IV RATE JS TOO FAST
Red man syndrome
How does red man or red neck syndrome look like?
It hung
Flushing
Hypotension
Tachycardia
Can be fetal
Phlebitis - IV
Vancomycin is what?
Ototoxic and nephrotoxic
What is ketolides used for?
Side effects same thing as macrolides
- statins ( rhabdomyolysis )
- warfain ( bleeding )
Community Acquired pneumonia
Ketolixes have increase levels of antibiotic in the body when taken with?
Antilipidemics
