Chapter 28 Flashcards
(22 cards)
What are the two main forms of lipids in the blood
Triglycerides
Cholesterol
What makes a lipoprotein
Triglyceride/Cholesterol with apolipoprotein
Is low density lipoprotein or high density lipoprotein better for the body
HDL
Where does lipid metabolism occur
Liver
What is the Framingham risk score
Ratio of HDL to LDL
What are the 4 types of antilipemics
HMG-CoA reductase inhibitors (statins)
Bile acid sequestrants
B vitamin niacin
Fibric acid derivative
What type of medication is not an antilipemic but is used to achieve the same goal
Cholesterol absorption inhibitor
What is the goal of antilipemics
Decrease LDL, increase HDL
What antilipemic is the first line therapy for hyper cholesterolemia
Statins
What do statins do
Decrease blood cholesterol levels
What is an adverse effect of statins
Rhabdomyolysis
What is Rhabdomyolysis
Breakdown of muscle protein
Why are statins usually taken at night
Cholesterol is mainly produced by the body when it is asleep
What do bile acid sequestrants do
Prevent reabsorption of bile acids in small intestine. Bile acid needed to absorb cholesterol
What drug is commonly used as an adjuvant with statins
Bile acid sequestrants
High doses of which antilipemic drug decrease the absorption of fat soluble vitamins A D E K
Bile acid sequestrants
What do niacins do
Reduce metabolism of cholesterol and triglycerides, LDL decrease, HDL increase
Niacin taken with which other antilipemic drug increases risk for myopathy
Statins
What do fibric acid derivatives do
Activate lipoprotein lipase to break down cholesterol
Gemifibrozil enhances the action of which drug
Anticoagulants
What do cholesterol absorption inhibitors do
Inhibit absorption of cholesterol from small intestine
Can cholesterol absorption inhibitors be used with fibric acid derivatives
