Chapter 3 Flashcards
(23 cards)
what is hematopoeisis?
it is the process of production of blood in the blood.
give the 3 phases of Intrauterine hematopoiesis
- mesoblastic/megaloblastic phase
- hepatic phase
- medullary/myeloid phase
explain each part of the phases
main sites of adult hematopoiesis
- skull, shoulder blades, and sternum
- ribs
- pelvis and proximal ends of long bones
- vertebrae
components of bone marrow
Newborn: 80-90% is active red marrow
- Young adult (20y/o): 60% is active red marrow
- Older adult (55y/o): 40% is active red marrow, 60% is
inactive yellow (fatty) marrow
components of bone marrow
Newborn: 80-90% is active red marrow
- Young adult (20y/o): 60% is active red marrow
- Older adult (55y/o): 40% is active red marrow, 60% is
inactive yellow (fatty) marrow
collection site for bone marrow and the preferred sites.
- posterior iliac crest (preferred)
- anterior iliac crest (preferred)
- sternum
- anterior medial surface of the tibia
- spinous vertebrae, and other red marrow containing bones.
give the marrow cellularity and explain each
- Normocellular: marrow has 30-70% hematopoietic
cells - Hypercellular/ hyperplastic: marrow has >70%
hematopoietic cells - Hypocellular/ hypoplastic: marrow has <30%
hematopoietic cells - Aplastic – marrow has few or no hematopoietic cells
normal ration of M:E
M:E with leukemia
3: 1 - 4:1
10: 1
normal ration of M:E
M:E with leukemia
3: 1 - 4:1
10: 1
Marrow differential
500 cells (preferred: 100o cells) 500 cells on each slide
white pulp and red pulp consist of what?
white pulp contain wbc, while red pulp consists of blood (old and abnormal RBC are destroyed)
what are the functions of spleen?
- reservior: 30% platelets are stored
- RBC filtration: RBC with cytoplasmic inclusions, old or abnormal are destroyed by the splenic macrophages
- cellular grooming and restructuring: reticulocytes are delayed because of small among of RNA.
- cytoplasmic inclusions are squeezed or compressed. (DNA, RNA, Iron, and etc)
what are the functions of spleen?
- reservior: 30% platelets are stored
- RBC filtration: RBC with cytoplasmic inclusions, old or abnormal are destroyed by the splenic macrophages
- cellular grooming and restructuring: reticulocytes are delayed because of small among of RNA.
- cytoplasmic inclusions are squeezed or compressed. (DNA, RNA, Iron, and etc)
what are the functions of spleen?
- reservior: 30% platelets are stored
- RBC filtration: RBC with cytoplasmic inclusions, old or abnormal are destroyed by the splenic macrophages
- cellular grooming and restructuring: reticulocytes are delayed because of small among of RNA.
- cytoplasmic inclusions are squeezed or compressed. (DNA, RNA, Iron, and etc)
what are the functions of spleen?
- reservior: 30% platelets are stored
- RBC filtration: RBC with cytoplasmic inclusions, old or abnormal are destroyed by the splenic macrophages
- cellular grooming and restructuring: reticulocytes are delayed because of small among of RNA.
- cytoplasmic inclusions are squeezed or compressed. (DNA, RNA, Iron, and etc)
what are the functions of spleen?
- reserviors: 30% platelets are stored and lymphocytes.
- RBC filtration: RBC with cytoplasmic inclusions, old or abnormal are destroyed by the splenic macrophages
- cellular grooming and restructuring: reticulocytes are delayed because of small among of RNA.
- cytoplasmic inclusions are squeezed or compressed. (DNA, RNA, Iron, and etc)
describe asplenia and what are the factors affected with it
aslenia is the absence of splenic function. it can be due to surgical operation
what is splenomegaly?
it is the enlargement of spleen.
what are the results of splenomegaly?
- vascular congestion and portal hypertension
- RBC, WBC, and 90% platelets are trapped, that could result to anemia, thrombocytopenia, and leukocytopenia
what are the two lymphoid tissue?
- primary lymphatic tissue
- secondary lymphatic tissue
explain the two lymphoid tissue
- primary lymphatic tissue consist of B lymphocytes that came from Bone marrow, and T lymphocytes produced from Thymus.
- secondary lymphatic tissue serves as reservoirs for already differentiated lymphoid.
- it includes lymph nodes, spleen and gut associated with lymphatic tissue.
explain the two lymphoid tissue
- primary lymphatic tissue consist of B lymphocytes that came from Bone marrow, and T lymphocytes produced from Thymus.
- secondary lymphatic tissue serves as reservoirs for already differentiated lymphoid.
- it includes lymph nodes, spleen and gut associated with lymphatic tissue.
