Chapter 3 Flashcards by Neha M

Q

peptide general structure

A

amino acid chains

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Q

catecholamine general structure

A

tyrosine derivative

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Q

thyroid general structure

A

iodinated tyrosine derivative

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Q

steroid general structure

A

cholesterol derivative

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Q

peptide solubility

A

water-soluble

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Q

catecholamine solubility

A

water-soluble

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Q

thyroid solubility

A

lipid-soluble

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Q

steroid solubility

A

lipid-soluble

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Q

peptide transport in blood

A

dissolved in plasma

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Q

catecholamine transport in blood

A

dissolved in plasma or bound to carrier proteins

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Q

thyroid transport in blood

A

bound to carrier proteins

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Q

steroid transport in blood

A

bound to carrier proteins

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Q

peptide location of receptor

A

usually cell membrane

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Q

catecholamine location of receptor

A

cell membrane

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Q

thryroid location of receptor

A

intracellular

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Q

steroid location of receptor

A

intracellular

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Q

peptide general target response

A

modification of existing proteins

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Q

catecholamine general target response

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A

modification of existing proteins

Q

thyroid general target response

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A

induction of new protein synthesis

Q

steroid general target response

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A

induction of new protein synthesis

Q

peptide half life

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A

short

Q

catecholamine half life

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A

short or long depending on if its bound to carrier protein or not

Q

thyroid hormone half life

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A

long

Q

steroid half life

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A

long

peptide degradation/ metabolism

degraded by proteases; receptor-mediated endocytosis

catecholamine degradation/ metabolism

inactivated by COMT, MAO; receptor-mediated endocytosis

thyroid degradation/ metabolism

deiodinases

steroid degradation/ metabolism

conjugation; inactive form

peptide location of synthesis

RER and Golgi of several endocrine organs

catecholamine location of synthesis

cytoplasm of chromaffin cells in adrenal medulla

thyroid location of synthesis

thyroid colloid of follicular cells

steroid location of synthesis

cytoplasm and mitochondria of adrenal cortex, placenta, gonads

peptide production time

made in advance

catecholamine production time

made in advance

thyroid production time

made in advance

steroid production time

made on demand

peptide storage

stored in endocrine organs

catecholamine storage

stored in chromaffin cells

thyroid storage

stored in secretory vesicles

steroid storage

not stored (precursor cholesterol is stored)

peptide release

exocytosis

catecholamine release

exocytosis

thyroid release

simple diffusion

steroid release

simple diffusion