Chapter 3 (Based on Erin's SI notes)

Question 1

Synthetic Drugs

Answer 1

Fluoroquinolones
Metronidazole
Linezolid (Oxazolidnones)
Trimethoprim
Sulfonamides

Question 2

Isoniazid spectrum

Answer 2

Mycobacterium

Question 3

Aztreonam spectrum

Answer 3

Gram (-)

Question 4

Vancomycin spectrum

Answer 4

Gram (+)

Question 5

Fluoroquinolones spectrum

Answer 5

Everything

Question 6

Sulfonamides spectrum

Answer 6

Gram (+) and Gram (-)

Question 7

Aminoglycosides spectrum

Answer 7

Gram (+), Gram (-), and Mycobacterium

Question 8

Macrolides spectrum

Answer 8

Gram (+), Chlamydia, Rickettsia, Mycoplasma

Question 9

Tetracyclines spectrum

Answer 9

Gram (+), Chlamydia, Rickettsia, Mycoplasma, and some Gram (-)

Question 10

Static Drugs

Answer 10

Tetracycline
Macrolides/Ketolides
Lincosamides (Clindamycin)
Chloramphenicol
Streptogrammins
Oxazolidinones

Question 11

Cidal Drugs

Answer 11

Aminoglycosides
Beta Lactams
Vancomycin
Bacitracin
Isoniazid
Fosfomycin
Fluoroquinolones
Metronidazole
Rifampin
Polymyxins
Lipopeptides

Question 12

Tetracycline MOA

Answer 12

30s-block tRNA from binding during translation

Question 13

50S Subunit

Answer 13

Macrolides/Ketolides
Lincosamides
Chloramphenicol
Streptogramins
Oxazolidinones

Question 14

Aminoglycosides MOA

Answer 14

30s subunit; cause misreading of mRNA

Question 15

Beta Lactams MOA

Answer 15

inhibit PBPs

Question 16

Vancomycin

Answer 16

block cell wall synthesis and targets PTG

Question 17

Bacitracin

Answer 17

blocks cell wall synthesis

Question 18

Isoniazid

Answer 18

inhibits mycolic acid synthesis in mycobacterial cell wall

Question 19

Fosfomycin

Answer 19

blocks cell wall synthesis

Question 20

Fluoroquinolones

Answer 20

inhibit DNA gyrase (enzyme target)

Question 21

Metronidazole

Answer 21

impairs template strand of DNA; makes toxic intermediate

Question 22

Rifampin

Answer 22

inhibits RNA polymerase (enzyme target)

Question 23

Polymyxins

Answer 23

disrupt cell membrane

Question 24

Trimethoprim

Answer 24

inhibits dihydropterate synthetase (DPS enzyme)

prevents folates from forming to create adenine, guanine, thymine, fMET tRNA

Question 25

Sulfamethoxazole

Answer 25

inhibit Dihydrofolate reductase (DHFR enzyme) | prevents folates from forming to create adenine, guanine, thymine, fMET, tRNA

Question 26

Lipopeptides

Answer 26

targets inner cell membrane

Question 27

Polymyxins

Answer 27

targets inner cell membrane

Question 28

Viruses treated with vaccines and drugs

Answer 28

Influenza Chronic Hep B Genital warts Varicella

Question 29

Drugs to treat influenza

Answer 29

Zanamivir Osettamivir Amantadine Rimantidine

Question 30

Drugs to treat chronic Hep B

Answer 30

interferon alpha-2b | lamivudine (NRTI)

Question 31

Drugs to treat Genital warts

Answer 31

interferon alpha-2b

Question 32

drugs to treat Varicella

Answer 32

"-ovir" drugs

Question 33

Viruses treated with drugs/no vaccine

Answer 33

Hep C HIV/AIDS Respiratory illness in infants HHV6

Question 34

Hep C drugs

Answer 34

interferon alpha-2a/2b

Question 35

HIV/AIDS drugs

Answer 35

NRTIs | NNRTs

Question 36

NRTIs

Answer 36

competitive inhibitors or substrates prodrug parent drug needs to be converted to active triphosphate form no 3'OH group which terminates DNA chain

Question 37

NNRTs

Answer 37

noncompetitive not prodrugs not incorporated into viral DNA so bugs will build resistance rapidly

Question 38

Respiratory illness in infants drug

Answer 38

ribavirin

Question 39

HHV6 drugs

Answer 39

"-ovir" drugs