Chapter 5- Adverse Drug Effects And Drug Interactions

Question 1

Side Effects

Answer 1

Predictable drug effects that may occur even at therapeutic doses

Question 2

What is FAERS

Answer 2

The FDA’s Adverse Event Reporting System

Question 3

Drug Allergies

Answer 3

Common event, defined as a hyper response of body defenses to a particular drug that may result in a diverse range of pt symptoms

Question 4

Drug interaction

Answer 4

When a medication interacts with another substance such as another drug, dietary supplement, herbal product, or food that is taken concurrently with the medication, and the drug’s actions ARE affected

Question 5

Idiosyncratic response

Answer 5

An adverse drug effect that produces unusual and unexpected symptoms that are not related to the pharmacologic action of the drug

Question 6

Teratogens

Answer 6

Agents that cause birth defects

Question 7

What is the relation of GFR to drug excretion?

Answer 7

The higher the GFR, the more rapid the excretion

Question 8

Additive Effect

Answer 8

Two drugs from a similar therapeutic class produce a combined summation response (used extensively in the tx of HTN)

Question 9

Synergistic Effect

Answer 9

Drug interaction that produces an enhanced response. The effect of the two drugs is greater than would be expected from simply adding the two individual drugs’ responses

Question 10

Antagonistic Effect

Answer 10

Drug interaction that occurs when adding a second drug results in a diminished pharmacologic response (can result in drugs being “canceled”)

Question 11

What does it mean when a drug handbook states adverse effects are “dose related?”

Answer 11

As the dose increases, the risk of adverse effects also increases