CHAPTER 5 - INTERFERONS Flashcards
(53 cards)
Cytokine family produced by leukocytes regulating immune responses
Interleukins (ILs)
Monocyte/macrophage-derived proinflammatory pyrogen
IL-1α/β
IL-1 receptor antagonist blocking immune activation
IL-1RA
T-cell growth factor enhancing cytotoxic cell activity
IL-2
Hematopoietic cytokine supporting multipotent progenitor cells
IL-3
Th2-polarizing cytokine inducing IgE class switching
IL-4
Eosinophil-activating cytokine driving mucosal immunity
IL-5
Acute-phase response inducer via hepatocyte signaling
IL-6
Lymphoid progenitor growth factor for B/T cell development
IL-7
Neutrophil chemoattractant activating respiratory burst
IL-8
Mast cell growth factor promoting Th9 differentiation
IL-9
Anti-inflammatory cytokine suppressing APC function
IL-10
Megakaryocyte-stimulating hematopoietic synergist
IL-11
Th1-polarizing cytokine enhancing IFN-γ production
IL-12
IL-4 homologue suppressing macrophage activation
IL-13
B-cell growth factor implicated in B-cell lymphoma
IL-14
NK cell activator maintaining memory T cell pools
IL-15
CD4+ T cell chemoattractant activating monocytes
IL-16
Neutrophil-recruiting cytokine mimicking TNF-α effects
IL-17
IFN-γ inducer synergizing with IL-12 for antitumor immunity
IL-18
IL-10 homologue regulating macrophage polarization
IL-19
Keratinocyte regulator involved in skin inflammation
IL-20
B/T cell regulator enhancing NK cell cytotoxicity
IL-21
Epithelial protector with IL-10-like mucosal activity
IL-22
