Chapter 5 - Prions

Question 1

Transmissible Spongiform Encephalopathies

Answer 1

Can occur sporadically or through transmission

Examples are kuru, CJD, vCJD, BSE, scrapie, chronic wasting disease

Question 2

Symptoms of TSEs

Answer 2

personality changes, psychiatric problems such as depression, lack of coordination, involuntary jerking, insomnia and memory problems, severe mental impairment

Question 3

Prion

Answer 3

short of proteinaceous infectious particle

not killed by autoclave

Question 4

How is BSE controlled in the US?

Answer 4

monitor carcasses, ban use of high-risk tissue

Question 5

Scrapie

Answer 5

sheep and goats, oldest known and most widespread TSE. transmissed through contact with placenta or associated fluids. There are scrapie resistant genotypes. Not transmissible to humans

Question 6

BSE

Answer 6

cattle, mad cow disease. vCJD is linked to ingestion of contaminated beef.

Question 7

risk attitude and risk perception

Answer 7

perceptions reflect interpretation

attitude reflects a consumer general predisposition to risk in a consistant way

Question 8

KD and KO of PrP in goats and cattle

Answer 8

Production of cattle lacking prion protein
Tested using western blot test (detects specific proteins)
It was successful
tested for level of expression