Chapter 54 Flashcards
(12 cards)
1
Q
What drug is used to rescue methotrexate?
A
leucovorin
2
Q
What drug is used to rescue cyclophosphamide?
A
mesna
3
Q
What drug is used to rescue doxorubicin?
A
Dexrazoxane
4
Q
Which anti-neoplastic produces hydrogen peroxide as its MOA?
A
Procarbazine
5
Q
Does methotrexate lead to the decrease in synthesis of purines of pyrimidines?
A
purines
6
Q
What enzyme degrades 6-MP?
A
allopurinol
7
Q
What phase of the cell cycle do the vinca alkaloids inhibit?
A
S-phase
8
Q
What is MOA of vinca alkaloids?
A
prevent assembly of mitotic spindle
9
Q
What is MOA of paclitaxel and docetaxel?
A
prevent disassembly of mitotic spindle
10
Q
Which anti-neoplastic is fatal during G2?
A
bleomycin
11
Q
What receptor does cituximab target?
A
EGFR
12
Q
What cancer is erlotinib used to treat?
A
metastatic small cell lung
