chapter 6! Flashcards
(22 cards)
what subset of Cd4 helper t cell has the role in disease of autoimmunity; chronic inflammation and target cells are macrophages?
Th1
what subset of Cd4 helper t cell has the role in disease of allergy and target cells are eosinophils?
Th2
what subset of Cd4 helper t cell has the role in disease of autoimmunity and target cells are neutrophils?
Th17
what cytokine’s principle action is t cell proliferation and regulatory t cell survival
IL-2 (Th1)
what cytokine’s principle action is activation of macrophages
IFN-y (Th1’s signature cytokine)
what cytokine’s principle action is inhibition of T cell activation and differentiation of regulatory t cells
TGF-B
(inhibitor)
these subset cells result in classical macrophage activation (enhanced microbial killing)
Th1 cells
this subset is induced by microbes/bacteria that are ingested by phagocytes
Th1 cells
what are the cytokines that are secreted from the macrophage response when Th1 cells activate them?
TNF, IL-12, IL-1
B7 molecules also have increased expression
this subset is induced by parasitic worm infections
th2 cells
signature cytokines for th2 cells
IL-4, IL-5, IL-13
what is the antibody produce during antibody production in th2 cells
IgE
what are the functions of th2 cells
mast cell degranulation, intestinal mucus secretion and peristalsis (gut), and eosinophil activation
binding of eosinophils and IgE in th2 cells, will cause
eosinophils to release they granules and promote helminth death
th1 cytokine ____ inhibits th2 and th17 developmental possibilities
IFN-y
this subset of cd4 t lymphocyte has microbrioal actions such as phagocytosis and killing of bacteria/fungi AND causes inflammation
th1: classically activated macrophage M1
via IFN, and TLR ligands
this subset of cd4 lymphocyte has antiinflammatory effects, wound repair, and fibrosis (inhibitions inflammation)
Th2: alternatively activated macrophage (M2)
via IL-13 and IL-4
th2 cytokines _____ and ____ inhibit classical macrophage activation (m1)
il-4 and il-13
this cd4 t lymphocyte subset’s signature cytokines are IL-17 and IL-22
th17 cells
this subet’s major function is recruitment of neutrophils, resulting in inflammation
th17 subset
during the development and function of Cd8 cytotoxic t lymphocytes, this facilitates entry of granzymes into the cytosol during CTL activation, granzymes then activate apoptosis.
perforin
what additional mechanism is required for CD4+ effector T cell bound to MHC II molecule plus antigen on macrophage to activate the macrophage killing function?
CD40 ligand on t cell binding to CD40 on macrophage
