Chapter 7: Plasma membrane function Flashcards
(43 cards)
Plasma Membrane (PM)
is the boundary that separates living cell from its surroundings.
PM exhibits selective permeability,
allowing some substances to cross it more easily than others.
Variations in LIPID composition of PM of many species…
are adaptations to specific environmental conditions.
Ability to change the lipid compositions in response to temperature changes has evolved in organisms that live where temperatures vary.
Lipids are hydrophobic because they consist mostly of hydrocarbons, which form nonpolar covalent bond
Phospholipids are the most
abundant lipid in the PM
Phospholipids are
amphipathic molecules, containing hydrophobic and hydrophilic regions
Fluid mosaic model
states that a membrane is a fluid structure with a “mosaic” of various proteins embedded in it
Phospholipids in the PM can move within the bilayer
– Most of the lipids, and some proteins, drift laterally
– Unlikely for a molecule to flip-flop transversely across PM
As temperatures cool, membranes switch from a fluid state to a solid state
– Temperature at which a membrane solidifies depends on the types of lipids & steroid cholesterol the PM contains
– At moderate temperatures, cholesterol reduces membrane fluidity; at low temperatures, it hinders solidification
Membranes rich in unsaturated fatty acids are more fluid than
those rich in saturated fatty acids
Membranes must be fluid to work properly; they are usually about
as fluid as salad oil
A membrane is a collage of different proteins,
embedded in fluid matrix of lipid bilayer
There are different types of
– Integral membrane proteins
– Peripheral proteins
Proteins determine most of the
membrane’s specific functions
Major functions of membrane proteins
– Transport; Enzymatic activity – Signal transduction – Cell-cell recognition – Intercellular joining – Attachment to the cytoskeleton and extracellular matrix (ECM)
Membranes have
distinct inside and outside faces
The asymmetrical distribution of proteins, lipids, and associated carbohydrates in the PM is determined
when membrane is built by products made in the ER and Golgi apparatus
A process PM controls
A cell must exchange materials with its surroundings
As PM are selectively permeable, they regulate cell’s molecular traffic
- Hydrophobic (nonpolar) molecules, and gases can dissolve in the lipid bilayer and pass through the membrane rapidly
- Polar molecules (such as sugars) do not cross membrane easily
- Hence, small/uncharged/nonpolar/lipid-soluble molecules pass most easily thru the lipid core of a PM
Passive Transport
is diffusion of a substance across a membrane with no energy investment
DIFFUSION
is the tendency for molecules to spread out evenly into the available space
Although each molecule moves randomly,
diffusion of a population of molecules may be directional
At dynamic equilibrium,
molecules cross the membrane at the same time.
Substances diffuse down their concentration gradient
(the region along which the density of a chemical substance increases or decreases)
– No work must be done to move substances down the concentration gradient