Chapter 8 Flashcards
(23 cards)
What is Hemoglobin (Hb)
a large complex protein molecule found inside the erythrocyte (RBC).
What must be present for oxygen to bind
Heme, iron and globin
What is oxyhemoglobin (HbO2)
Hb combined with oxygen
bright red blood (arterial blood)
What is deoxyhemoglobin (Hb)
when not bound with oxygen
deep purple blood (venous blood)
How does blood carry oxygen?
O2 is carried in the blood in two forms, dissolved and combined with hemoglobin
% of O2 carried in the blood that is bound to hemoglobin?
98%
Normal Hb range
12 - 16 g/dl
When Hb is fully saturated with O2, each gram of Hb carries how much of O2?
1.34 ml
Hemoglobin equation
Hb of 15 g/dl x 1.34 ml of O2 x SaO2% (1) = 20.1 ml/dl
Terms of hemoglobin (2)
anemia -low hemoglobin levels
polycythemia - high hemoglobin levels
Steps of O2/Hb
- O2 from lungs
- O2 bounds to Hb
- O2 releases to tissue cells
Normal SaO2 = ?
97.5 % at PaO2 of 100 mmHg
Normal SVO2 = ?
75% at PVO2 of 40 mmHg
SaO2 of 100% = ?
fully saturated hemoglobin
Sigmoid curve = ?
cooperative binding
Steep portion = ?
rapid loading or unloading of oxygen
What does the hemoglobin dissociation curve is represent?
graphical representation of the relationship between partial pressure of oxygen (pO2) and the saturation of hemoglobin with oxygen (SO2)
What does the hemoglobin dissociation curve illustrate?
how readily hemoglobin binds and releases oxygen molecules in response to changes in oxygen tension
P50 = ?
27 mmHg and 50% SaO2
Lower P50 = ?
Left shift
PCO2 decreased
pH elevated
decreased temp
decreased 2,3 -DPG
Higher P50 = ?
right shift
PCO2 elevated
pH decrease
temp elevated
2,3 -DPG decreased
Bohr effect helps with what?
metabolizing tissues release oxugen from oxuhemoglobin
