Chapter 8 - Carboxylic Acids Flashcards
(4 cards)
1
Q
Define a carboxylic acid
A
carbonyl + hydroxyl
Liquids with high boiling points due to polarity and H bonding, water soluble and soluble in dilute bases NaOH
*most acidic = most electronegative
2
Q
Which is stronger
CH3CH2-CClCOOH
CH3-CCl2-CH2COOH
A
Top is stronger as Cl is closer to carboxyl. Cl and NO2 stabilise and increase acidity.
e- donating groups like NH2 and OCH3 destabilise and decrease acidity
3
Q
What are some of the ways to synthesise carboxylic acids
A
Oxidative cleavage of alkenes/alkynes
Oxidation of primary alchols and aldehydes
Hydrolysis of nitriles under strong conditions
Carboxylation of grignards
4
Q
What is the relationship between acidity, ka and pka
A
Larger the pKa the weaker the acid
High Ka = strong acid = Low pKa
