Chapter 8: Genetics Flashcards

(59 cards)

1
Q

Genetics

A

Study of the transfer of genes from parents to offspring

The nature in nature vs nurture

Genotype is an organism’s genetic makeup

Phenotype is how genes are expressed

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2
Q

Animal Breeding

A

Humans have understood for centuries that parents pass traits to offspring

Through domestication humans selectively bred individuals for desired traits

Docility, intelligence, strength, coat quality, fat content, milk production, appearance

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3
Q

Genetics: What are Genes?

A

Nucleus holds chromosomes

Chromosomes are made of DNA

Pairs of chromosomes

Genes are segments of DNA

Code for specific proteins, control biochemical processes

Blueprint of life

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4
Q

DNA

A

Deoxyribonucleic acid
Double strand of nucelotides= deoxyribose sugar, phosphate, nitrogenous base

Purines- adenine (A) and guanine (G)

Pyrimidines- thymine (T) and cytosine ©
A to T and G to C

Genes are made of sequence of base pairs

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5
Q

Genome

A

Genome is all the genes for an organism

Different species have different numbers of chromosomes, genes

DNA must be supercoiled to fit thousands of genes per chromosome

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6
Q

Somatic Cells

A

Somatic cells- body cells have 2 pairs, diploid (2n)

Humans- 46, 23 pairs

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7
Q

Gametes

A

reproductive cells 1 pair, haploid (n)

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8
Q

Sex Chromosomes

A

have genes related to sex characteristics, Autosomes- everything else

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9
Q

Sex Determination

A

In mammals males are XY (sperm), females are XX (egg)

In chickens females are ZW, males are ZZ

Crocodilians, turtles temperature dependent

Amphibians, fish lots of forms of determination

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10
Q

Chromosome Number

A

Expressed as n, Varies widely

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11
Q

Polyploidy

A

more than 2 copies of chromosomes, or whole genome

Mistake during cell division

Not common in vertebrates, widespread in plants, can cause low seed production

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12
Q

Aneuploidy

A

variation in number of individual chromosomes

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13
Q

Monosomic

A

one less (2n-1)

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14
Q

Trisomy

A

one more (2n+1)

Often lethal, sometimes not.

Down’s syndrome caused by Trisomy of chromosome 21

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15
Q

DNA Replication

A

Must be accurate to prevent mistakes in offspring

DNA molecule unzips, RNA primer attaches to DNA polymerase

Polymerase moves down original strand

Bonds new nucleotides together to original strand, polymerization

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16
Q

DNA Replication: When do we do it?

A

Anytime body cells (somatic cells) divide

Growth, injury, maintenance

Anytime sex cells (gametes; sperm, eggs) divide

Reproduction

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17
Q

Mitosis

A

Somatic cell division, produces two 2n cells- 2 copies of chromosomes

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18
Q

Meiosis

A

Reproductive cell division, produces 4 n cells-1 copy of chromosomes

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19
Q

Principle of Inheritance

A

1866 Gregor Mendel discovered principles of inheritance while studying pea plants

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20
Q

Alleles

A

forms of a given gene, each creates different proteins, so express traits differently, get one copy from each parent

Chromosomes in homologous pairs, genes for the same traits

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21
Q

Locus

A

is a certain spot on chromosome

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22
Q

Animals with matching alleles at a locus

A

Homozygous, (AA or aa) different alleles are Heterozygous (Aa)

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23
Q

Inheritance

A

is passing of alleles in gametes

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24
Q

gamete production

A

pairs separate

25
Law of Segregation
alleles separate so only one per gamete
26
Law of Independent Assortment
separation of a pair of genes is independent of separation of other pairs
27
Gene Expression: Complete Dominance
Dominant alleles mask recessive alleles and are expressed over them, signify dominant allele with capital letter EE colored coat, ee white, Ee colored EE is the genotype, colored is the phenotype
28
Punnett Square
Used to predict the results of a genetic cross In a genetic cross, two parents (P generation) are crossed to produce offspring (F1 generation). The simplest Punnett square follows one character in a monohybrid cross.
29
Test Crossing
Can’t always tell genotype by looking at phenotype Can test cross individual with homozygous recessive to see what offspring are If some recessive, then parent is heterozygous
30
Codominance
neither allele masks the other, both are expressed Red coat (RR) + white coat (WW) = roan (RW)
31
Incomplete dominance
heterozygous individual is intermediate
32
Epistasis
expression of one gene is influenced by the presence of another Defies classical Mendelian genetics Horse hair color black is E at E locus, but whether black all over or just points is controlled by another locus Ea is black, EA is bay with black points
33
Multiple alleles
only 2 alleles on each locus, but population could have many alleles A-B-O blood types in humans
34
Polygenic inheritance
is the effect of many genes on a single character. In humans, height and skin color are each affected by several genes. Size and growth rates common in animals
35
Sex-Linked Inhertiance
Some genes only found on X or Y, homologous in some regions, not in others X-linked genes can be inherited by males and females Y-linked only in males Found on autosomes, phenotypes are not expressed the same way for the sexes In male sheep horns (H) is dominant to polled (no horns(h)), in females h is dominant So heterozygous male has horns, hetero female doesn’t
36
Sex-Limited Traits
Traits unique to a single sex Milk production, egg production Both have genes, but only one sexes expresses them
37
Gene frequency
proportion of a particular allele in a population
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Genotypic frequency
how often a genotype occurs in a population
39
Phenotypic frequency
how often a phenotype occurs in a population
40
Animal breeding
uses pop genetics to improve livestock
41
Mutations
changes in the composition of a gene that alter DNA, producing new alleles Mutations that affect phenotype are rare Beneficial ones spread through natural selection
42
Genetic drift
change in gene frequency due to chance, affected by population size Big problem for small populations
43
Migration
wild animals migrating or bringing new breeding stock into a population Can make large changes in gene frequencies quickly this way Works best when new sire is very different from herd
44
Selection
allowing some animals to breed more than others
45
Natural Selection
some individuals are better adapted and will therefore breed more Happens in managed herds with multiple bulls Wild populations
46
Artificial selection
breeding controlled by manager, culling less desirable animals Affected by rate of reproduction and generation time
47
Hardy-Weinberg Law
In a large, randomly mating population without natural selection, migration, or mutation, gene frequencies will remain stable Rare in the wild, common in managed herds Once desired genes are achieved in a large herd, they will remain constant
48
Qualitative traits
phenotypes classified into groups Coat color, horn presence
49
Quantitative traits
numerically measured, usually polygenic Growth rate Additive gene action- no dominance at locus, each gene increases the effect A+ gene makes calves 2lbs heavier at birth, AA is norm, A+A+ is 4lbs heavier
50
Nature vs. Nurture
Genes determine your potential, but environment determines if live up to that potential Climate, management practices, health
51
Heritability
How much phenotypic variability among individuals that is due to genetics and can be passed down Ranges from 0-1 First calculate a selection differential- difference between the population and desired trait, multiply by heritability value Need to be considered before breeding Pig litter size- norm is 7, breed parents from litters of 11 Differential is 11-7= 4 Heritability value is .1, so 4x.1= .4 So litter will be 7.4 piglets larger Some traits are more heritable than others
52
Relationship Coefficient
Measures how closely related individuals are, also important before breeding. Ranges from 0-1 Parent-offspring- 0.5 Siblings- 0.5 Half-Siblings- 0.25 Grandparent-offspring- 0.25
53
Inbreeding
mating closely related individuals Increases homozygosity, decreases genetic variation Can increase incidence of detrimental recessive traits Causes decline in quality called inbreeding depression
54
Linebreeding
inbreeding to concentrate genes of an outstanding ancestor Genetic evaluations have eliminated need for this in livestock, but still practiced in companion animals
55
Outbreeding
mating less closely related individuals Increases heterozygosity, genetic diversity Increases vigor, known as heterosis Lowly heritable traits show more heterosis
56
Crossbreeding
mating animals of different breeds Most successful if parent genetics complement each other Strengthen good traits, depress bad ones Great for reproductive traits Often breed crossbred mothers with purebred sires Tend to be more vigorous, fertile, and healthy
57
Biotechnology
Tools that use living organisms to make improvements or modifications for specific uses
58
Genetic engineering
altering an animals genes
59
Transgenic Organisms
Bacteria that produce human insulin Before used pig and cattle insulin, slightly different Cows, sheep, goats can produce proteins in milk to treat disease Can produce large quantities Chickens can produce proteins in eggs Animal models for human diseases Animals to produce organs for human transplant