Chapter 9 - Schizophrenia Flashcards

(51 cards)

1
Q

What does schizophrenia mean

A

Split mind

  • psychotic disorder, loss of contact with reality
  • most severe debilitating
  • most patients unable to care for themselves
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Stats on schizophrenia

A
  • 10-20% of homeless
  • 40-60% live w family
  • begins early in life (16-25)
  • Suicide rates 8-10%
  • 2x as common as Alzheimers
  • 5x as common as MS
  • 300x as common as Cystic fibrosis
  • 1/100 ppl diagnosed, 300k in canada
  • 1/12 hospital beds
  • $6.85 billion annually in Canada
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Groups of symptoms of schizo

A

1) Disordered thinking (speech)
2) Delusions (false beliefs)
3) Hallucinations
4) Disorganized motor behaviour (gross disorganized or catatonic)
5) Negative symptoms

1-4: Positive symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Details of disordered thinking symptoms

A
  • Formal thought disorder (form/style not content)
  • Inchoherence - word salad
  • Neologisms - new (neo) words (logos)
  • loose associations
  • perseveration (stuck in one line of thinking - Wisconson card sort task
  • thought blocking
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Details of delusions symptoms

A

Types

  • Reference (things have special significance)
  • grandeur
  • control (controlled by external)
  • persecution
  • somatic

Thought insertion
thought broadcasting
thought withdrawl (others removing thoughts frm head)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Most common form of hallucination

A
  • auditory
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

two types of disorganized motor behaviour

A

1) Disorganized - pacing, agitated, strange dress, talking,

2) Catatonic - waxy flexibility

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Describe Negative symptoms

A
  • Alogia - poverty of speech (a - lack of; logia - speech)
  • anhedonia
  • flat affect
  • avolition - lack of motivation
  • social withdrawl (one of the first signs)
  • these are less responsive to antipsychotic meds
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Name the positive symptoms of schizo

A
  • disordered thinking
  • delusions
  • hallucinations
  • disorganized motor behaviour
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Define Alogia, Anhedonia, Avolition

A

Alogia - poverty of speech
Anhedonia - loss of enjoyment of pleasurable activities
Avolition - lack of motivation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Phases of Schizophrenia

A

Prodromal -> Active -> Residual

  • Prodromal: clear deterioration of functioning
  • Residual: attenuated symptoms following active phase
  • tends to be episodic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Diagnostic criteria for active phase

A
  • at least one month
    1) 2 or more symptoms
  • delusions, hallucinations, diorganized speech, gross disorganized or catatonic behaviour, negative symptoms
  • or -
    2) 1 symptom if
  • bizarre delusion; or, auditory hallucination of voice keeps a running commentary, or two or more voices conversing

Bizarre: impossible
Non-bizarre: could possibly be true (plot to be killed by neighbour)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Diagnostic criateria for schizophrenia

A
  • active phase at least 1 mos
  • all phases at least 6 months

If less than 6 months:

  • Brief psychotic disorder (<1 mos)
  • schizophreniform disorder (1-6 mos)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Subtypes of schizophrenia

A

1) Paranoid type
2) Disorganized
3) Catatonic
4) Undifferentiated
5) Residual

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which subtype has best and worst prognosis

A

Best: paranoid
Worst: disorganized

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Features of paranoid subtype

A
  • delusions, auditory hallucinations (only)
  • no disorganized speech, behaviour or affect
  • most common, least severe
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Features of disorganized subtype

A
  • disorganized speech, behaviour

- inappropriate affect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Features of Catatonic subtype

A
  • immobile, waxy flexibility, mutism, posturing, grimacing, echolalia, echopraxia,
  • behaviour excitement, agitation
  • more common in less developed countries, was more common 50 yrs ago in N America
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Difference between Echolalia and Echopraxia

A
  • echolalia (repeat back others SAY)

- echopraxia (imitate BEHAVIOURS)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Undifferentiated subtype

A

doesn’t meet criteria for paranoid, disorganized, catatonic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Residual subtype

A
  • negative symptoms, attenuated positive symptoms

- no delusions, hallucinations, disorganized speech or behaviour

22
Q

Prognosis rates of schizophrenia

A
  • severity reduces with aging
  • 22% one episode only, complete recovery
  • 35% several episodes,normal functioning between
  • 8% several episodes, never return to normal between
  • 35% continual deterioration, reduced functioning between episodes

Shortened life-span (10 yrs reduction)

  • infectious diseases, circulatory disease
  • 8-10% suicide
23
Q

Prevalence rates of schizophrenia

A
  • 1% of population
  • men = women
  • men (15-24), women (25-34)
  • men more severe
  • similar rates around world
  • different symptoms around world
  • better recovery in developing countries (better social family networks) than in developed countries
  • more common in lower SES (Social drift theory)
24
Q

List other psychotic disorders

A

1) Mood disorder with psychotic features
2) brief psychotic disorder (<1 mos)
3) Schizophreniform disorder (1-6mos)
4) Schizzoaffective disorder
5) delusional disorder (erotomanic, grandios, persecutory, somatic)
6) Shared psychotic disorder (folie a deux)
7) Substance-induced psychotic disorders

25
Why is mood disorder w psychotic features tough to diagnose
- manic episode (mood) tough to distinguish frm schiz
26
Describe schizoaffective disorder
- all symptoms, but also symptoms of major depression or mania - 2 weeks of psych symptoms w no mood symptoms
27
Difference between paranoid and delusional disorder
- delusional disorder has non-bizarre disorder
28
Role of genetics
- MZ concordance is 48% - offspring w two schizo parents 47% - DZ concordance drops to 17% - polygenic (many genes) - epigenetics: environment/experiences influence whether genes are turned on
29
Describe dopamine hypothesis
- dopamine: movement, cognition (memory, attention, prob solving), motivation, pleasure, sociability - excess of dopamine in following areas: 1) Nigrostriatal - i.e. basal ganglia 2) Mesolimbic - limbic system, reward pleasure 3) Mesocortical - frontal lobes, motor areas - can be due to too much dopamine or too many receptors
30
Which receptors respond, which react to antipsychotic meds
Benefit: D2 receptors - positive symptoms (delusions, hallucinations) Worse: D1 receptors - negative symptoms (inadequate receptor binding)
31
Evidence of dopamine hypothesis
- effects of antipsychotic drugs | - effects of drugs that increase dopamine (amph, cocaine, L-dopa)
32
Other neurotransmitters possibly involved in schizo
- norepinephrine, glutamate, serotonin, GABA
33
Describe the neurophysiology of schizophrenia
- enlarged lateral ventricles | - cortical atrophy - esp frontal and temporal lobes, basal ganglia
34
Describe the four areas of the brain involved in schizophrenia, and their general functions
1) Frontal lobe - executive functions, avolition, personality change, working memory 2) Left temporal lobe - thought disorder, bizarre language, memory, selective attention 3) Right temporal lobe - flat affect, aprosodia, poor discrimination of facial emotion 4) Basal ganglia - fine motor control: rocking, pacing, stereotyped movements
35
What is aprosodia
unable to interpret meaning from tone of voice
36
Describe antipsychotic meds
1) traditional (50's-60s) - chlorpromazine, haloperidol - reduce positive symptoms - block dopamine receptors 2) Atypical antipsychotics (90's) - Clozapine, Risperidone, Olanzapine - target serotonin & dopamine - fewer side effects - long term mtce, high relapse
37
Describe typical side-effects of antipsych meds
- weight gain, anxiety, insomnia, dry mouth, constipation, low blood pressure, sex dysf - blurred vision, drowsy - parkinson tremors, rigidity (due to lack dopamine in Basal ganglia) - diabetes - tardive dyskinesia - Clozapine: immune suppression, weekly blood checks
38
Define bizarre delusions
clearly implausable and not understandable, do not derrive from everyday experiences
39
Type of schizophrenia in video
undifferentiated
40
Define Tardive dyskinesia
- loss of motor control from long-term antipsych use. - usually irreversable - due to brain's new dopamine production
41
Describe the psychosocial stress factors in psych
1) Stress - diathesis/stress model 2) Family communication patterns - expressed emotion - critical comments, hostility, emo overinvolvement, lack of warmth - increased risk of relaps (70% w hi family emo relapse) 3) Social class - neg assoc w SES - sociogenic theory - social drift hypothesis
42
Describe sociogenic theory, describe social drift hypothesis
Sociogenic: stress + poverty -> schizo - diathesis stress model, Social Drift hyp: those who are vulnerable get stuck in cycle. not that low ses causes vulnerable - perpetuates thru kids
43
Epigenetics (rat studies)
- social environment affect regulation, expression, function of genes Rats: - maternal care (licking, grooming, nursing) - experession of genes in hippocampus - regulation of stress response (HPA Axis) - differences in reactivity to stress later in life Humans: - gene expression similar to childhood abuse, neglect
44
Finnish study results
- dramatic increase in schizo expression when adopted in to brutal environment
45
Psychosocial treatments
- aimed at relieving triggers - Family Therapy - Social skills training - group therapy - stress management training - CBT - targets deficits in social interaction. How u see ppl around you
46
CBT vs Supportive counseling
- CBT stronger for positive and negative over supportive | - CBT for negative symptoms + antipsych meds for positive symptoms
47
What makes schizo different than other disorders
- heterogeneity (variety of symptoms, background, treatment response) - tough to predict how affected, prospects, or course of disorder
48
Types of markers and endophenotypes
Endophynotypes: vulnerability marker 1) Cognitive marker: reveals deficits in attention, working memory 2) Eye tracking - deviations from stimulus path
49
What is hypokrisia
- biological diathesis occurs througout brain, - not single gene tho - causes cognitive slippage - scrambled info
50
Define schizotype
- primary cognitve slippage and | - aversive drift (social withdrawl and disinterest)
51
Examples of neuropsych tests
- Wisconson card sorting - perseverate | - FAS techniqe: name words that begin with ...