Characteristic Molecular Alterations

Question 1

Adult type Astrocytoma

Answer 1

IDH1/IDH2 mutation

Question 2

Oligodendroglioma

Answer 2

IDH1/IDH2 mutation + Loss of 1p/19q

Question 3

Glioblastoma

Answer 3

IDH wild type
+7/-10
TERT mutation
EGFR amplification

Question 4

Pediatric diffuse astrocytoma

Answer 4

MYB, MYBL1 alteration

Question 5

Angiocentric glioma

Answer 5

MYB alteration

Question 6

PLNTY

Answer 6

BRAF and FGFR alterations

Question 7

Diffuse low-grade glioma (pediatrics)

Answer 7

MAPK pathway altered

Question 8

Diffuse midline glioma

Answer 8

H3 p.K28 (K27) altered
EGFR and EZHIP alterations

Question 9

Diffuse hemispheric glioma

Answer 9

H3 p.G34 (G34) mutant

Question 10

Diffuse pediatric type high grade glioma

Answer 10

H3 wild type + IDH wildtype
Methylome

Question 11

Infant type hemispheric glioma

Answer 11

RTK gene alteration

Question 12

Pilocytic astrocytoma

Answer 12

KIAA1549:BRAF fusion
BRAF alterations

Question 13

High grade astrocytoma with piloid features

Answer 13

Methylome

Question 14

PXA

Answer 14

BRAF alteration
CDKN2A alteration

Question 15

SEGA

Answer 15

TSC1
TSC2

Question 16

Chordoid glioma

Answer 16

PRKCA alteration

Question 17

Astroblastoma

Answer 17

MN1 altered
BEND2 alterations

Question 18

Granular cell tumors

Answer 18

BRAF alterations

Question 19

DNET

Answer 19

FGFR1 alterations

Question 20

Diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters

Answer 20

Methylome

Question 21

Papillary glioneuronal tumor

Answer 21

SLC44A1-PRKCA fusión

Question 22

Rosette-forming glioneuronal tumor

Answer 22

FGFR1 alterations
PIK3CA alterations
NF1 alterations

Question 23

Myxoid glioneuronal tumor

Answer 23

PDGFRA alteration

Question 24

Multinodular and vacuolating neuronal tumor

Answer 24

MAPK pathway alterations

Question 25

Dysplastic cerebellar gangliocytoma (Lhermitte-Duclos disease)

Answer 25

PTEN alterations

Question 26

Extraventricular neurocytoma

Answer 26

FGFR genes alterations (FGFR1:TACC1) IDH wildtype

Question 27

Supratentorial ependymomas

Answer 27

ZFTA (C11orf95) alteration YAP1 alteration

Question 28

Posterior fossa ependymoma type A

Answer 28

Reduction of H3 p.K28me Global DNA hypomethylation Hypermethylation of CpG islands

Question 29

Spinal ependmyoma

Answer 29

NF2 alterations MYCN alterations

Question 30

Medulloblastoma, WNT-activated

Answer 30

WNT pathway alterations

Question 31

Medulloblastoma, SHH-activated

Answer 31

SHH pathway alterations TP53 alterations

Question 32

AT/RT

Answer 32

SMARCB1 alterations SMARCA4 alterations

Question 33

Embryonal tumor with multilayered rosettes

Answer 33

C19MC alterations DICER1 alterations

Question 34

CNS neuroblastoma

Answer 34

FOXR2 alterations

Question 35

CNS tumor with BCOR internal tandem duplication

Answer 35

BCOR alterations

Question 36

Desmoplastic myxoid tumor of the pineal region

Answer 36

SMARCB1 alterations

Question 37

Meningioma

Answer 37

NF2 alterations AKT1 alterations TRAF7 alterations SMO alterations PIK3CA alterations

Question 38

Secretory meningioma

Answer 38

KLF4 + TRAF7 alterations

Question 39

Clear cell meningioma

Answer 39

SMARCE1 alterations

Question 40

Papillary and rhabdoid meningioma

Answer 40

PBRM1 alterations BAP1 alterations

Question 41

Anaplastic meningioma

Answer 41

TERT promotor mutation Homozygous deletion of CDKN2A/2B Loss of H3 p.K28me3

Question 42

Solitary fibrous tumor

Answer 42

NAB2:STAT6 fusion

Question 43

Meningeal melanocytic tumors

Answer 43

GNAQ, GNA11, PLCB4

Question 44

Meningeal melanocytic tumors (diffuse)

Answer 44

NRAS alterations

Question 45

Meningeal melanocytic tumors (circumscribed)

Answer 45

CYSLTR2 alterations

Question 46

Adamantinomatous craniopharyngioma

Answer 46

CTNNB1 alterations

Question 47

Papillary craniopharyngioma

Answer 47

BRAF alterations