Characteristics of some important adrenoceptors in the SANS Flashcards
(6 cards)
1
Q
ALPHA 1
- Location
- G protein
- 2nd messenger
- Major actions
A
ALPHA 1
- Location: smooth muscle, glands
- G protein: Gq
- 2nd messenger: Increase in IP3 and DAG
- Major actions: Increased Ca2+, causes contraction (vascular SM), secretion
2
Q
ALPHA 2
- Location
- G protein
- 2nd messenger
- Major actions
A
ALPHA 2
- Location: nerve endings, (some smooth muscle)
- G protein: Gi
- 2nd messenger: decrease in cAMP
- Major actions: decrease NT release (nerve), (contraction, SM)
3
Q
BETA 1
- Location
- G protein
- 2nd messenger
- Major actions
A
BETA 1
- Location: cardiac muscle, JGA
- G protein: Gs
- 2nd messenger: increase cAMP
- Major actions: increase HR and contractility, renin release
4
Q
BETA 2
- Location
- G protein
- 2nd messenger
- Major actions
A
BETA 2
- Location: smooth muscle, liver, heart
- G protein: Gs
- 2nd messenger: increase cAMP
- Major actions: relax bronchiolar SM; increase glycogenolysis; increase HR and contractility
5
Q
BETA 3
- Location
- G protein
- 2nd messenger
- Major actions
A
BETA 3
- Location: adipose cell
- G protein: Gs
- 2nd messenger: increase cAMP
- Major actions: increase lipolysis
6
Q
DOPAMINE 1
- Location
- G protein
- 2nd messenger
- Major actions
A
DOPAMINE 1
- Location: smooth muscle
- G protein:Gs
- 2nd messenger: increase cAMP
- Major actions: relax vascular SM in renal arterioles
