CHEMISTRY OF AMINO ACIDS

Question 1

Around pH, Carboxyllic acid will be

Answer 1

Ionized (-)

Question 2

Around pH 7, Amine group will

Answer 2

Be Ionized (+)

Question 3

Ionized are easily dissolved in H2O

Answer 3

True

Question 4

Solid amino acid has (MP)

Answer 4

Higher melting point

Question 5

Alliphatic Side Chains

Answer 5

Gly, Ala, Val, Pro, Ile, Leu, Met

Question 6

High Hydrophathy Index

Answer 6

Hydrophobic

Question 7

Low Hydrophathy Index

Answer 7

Hydrophillic

Question 8

Aromatic side chain

Answer 8

Phe, Tyr, His, Trp

Question 9

Polar Uncharged side chain

Answer 9

Ser, Thr, Cys, Asn, Gln, Tyr

Question 10

Negative charged polar side chain

Answer 10

Asp, Glu

Question 11

Positive charged polar side chain

Answer 11

Arg, Lys, His

Question 12

Essential amino acids

Answer 12

Source from diet

Question 13

Non essential amino acid

Answer 13

Can be synthesize by the body

Question 14

Separation of Amino Acids

Answer 14

Electrophoresis, and Chromatography

Question 15

High pI

Answer 15

Cathode -

Question 16

Low pI

Answer 16

Anode +

Question 17

Stationary phase

Answer 17

Polar

Question 18

Mobile phase

Answer 18

Nonpolar

Question 19

PVTTIMHALL

Answer 19

Phe, Val, Thr, Trp, Ile, Met, His, Arg, Leu, Lys

Question 20

L-Cysteine has

Answer 20

R configuration

Question 21

Functions of Proteins

Answer 21

Catalytic, Contractile, Hormonal, Protective, Receptors, Regulatory, Structural, Transport

Question 22

Catalytic

Answer 22

Enzymes

Question 23

Contractile

Answer 23

Actin, Myosin

Question 24

Hormonal

Answer 24

Insulin, hCG

Question 25

Protective

Answer 25

Fibrin, Immunoglobulins, Interferons

Question 26

Receptors

Answer 26

Nicotinic and adreganic recpetors

Question 27

Regulatory

Answer 27

Calmoudin, transcription factors

Question 28

Structural

Answer 28

Elastin, Keratin, Collagen

Question 29

Transport

Answer 29

Hemoglobin, Lipoproteins, Transferrin

Question 30

Primary structure

Answer 30

Joined by peptide bond

Question 31

Trans conformer of amino acids is

Answer 31

The most common

Question 32

Secondary structure

Answer 32

Ordered structure adopted by the chain through h bonds

Question 33

Types of secondary structures

Answer 33

Alpha helix, beta sheet, and beta turn

Question 34

Beta turn

Answer 34

4 consecutive amino acids, mostly proline and glycine, some are asparagine and aspartate

Question 35

Supersecondary structure

Answer 35

Higher than secondary but has no functions

Question 36

Forces stabilizing folding

Answer 36

Covalent, ionic, h bond, van der waals

Question 37

Chaperones

Answer 37

Involves in degradation and folding of proteins

Question 38

Prions

Answer 38

Misfolded proteins that causes disease

Question 39

Receptors and enzymes as drug targets

Answer 39

Most studied and largest groups of protein targets

Question 40

Carriers and transporters as drug targets

Answer 40

Have recognition sites for specific ligands

Question 41

Sttuctural proteins as drug targets

Answer 41

Most common in cancer, not usual target due to its low selectivity

Question 42

Peptide hormone as drugs

Answer 42

Insulin, Insulin lispro, and insulin aspart

Question 43

Insulin

Answer 43

Proline 28, glycine 29

Question 44

Insulin lispro

Answer 44

Proline 29, glycine 28

Question 45

Cutdown polypeptides as drugs

Answer 45

Part of the functional protein is given Poor gut absorption Rapid elimination Trigger immuno response

Question 46

Monoclonal antibodies

Answer 46

Identical antibodies produced by identical b lympocyte

Question 47

Zumab

Answer 47

Humanized

Question 48

Umab

Answer 48

Human

Question 49

Momab

Answer 49

Mouse urine

Question 50

Ximab

Answer 50

Chimeric

Question 51

Immunoglobulins

Answer 51

Mixture of antibodies Passive immunization

Question 52

Teriparatide (PTH)

Answer 52

Osteoporosis

Question 53

Etanercept

Answer 53

Rheumatoid arthritis