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Chemo Flashcards

(7 cards)

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1
Q

Doxorubicin (anthracyclines)

A

Binds Topoisomerase 2= cleave DNA and binds Fe= increase free radicals. Toxicity= dilated cardiomyopathy

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2
Q

Bleomycin

A

Free radical formation. Toxicity= pulmonary fibrosis

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3
Q

Cisplatin

A

Crosslinks DNA= decrease DNA synth. Toxicity= Nephrotox, ototox, peripheral neuropathy

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4
Q

Cyclophosphamide

A

Crosslinks DNA= decrease DNA synth. Toxicity= hemorrhagic cystitis. bladder Cancer

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5
Q

methotrexate

A

inhibits DHF-reductase. Toxicity= hepatotoxicity, hypersensitivity pneumonitis

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6
Q

Paclitaxel

A

inhibits MT disassembly. Toxicity= neuropathy

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7
Q

Vincristine/Vinblastine

A

binds B-tubulin= inhibit MT formation. Toxicity= neuropathy

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