Chemo Drugs Flashcards by Christy Finn

Vidaza

For bone marrow and blood cancers
Antimetabolite
Route: IV
Side Effects: decreased vitamin K levels
n/v/d/f

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Vectibix

For metastatic colon cancer
Monoclonal EGFR sensitive
Side Effect: D/low magnesium

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Sutent

(oral)

GIST, renal pancreatic, neuroendrocrine
Protein Targeted therapy
SE: n/v/d/decreased appetite, hand-foot sx, rash, can turn hair white
NO GRAPEFRUIT

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Epirubin (Ellence)

Breast
Antitumor ATB- Cell Cycle Specific
SE: N/V/D/mucositis/rash

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Gemzar

Pancreatic/bladder/breast/ovarian/lung
Antimetabolite-Cell Cycle Specific (pyrimide antagonist)
SE: n/v/pulmonary/flu like sx/clay colored stools

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Cytoxan (cyclophosphamide)

Breast, ovarian, CLL, lymphomas
Alkylating Agent (non cell cycle specific)
SE: BLADDER TOXICITY, N/v
PUSH FLUIDS
Give Mensa to prevent bleeding cysts
Can increase effect of anticoagulants

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Taxol (paclitaxel)

bladder, breast, ovarian, H&amp;N, Esophageal, lung, prostate pancreatic
Plant Alkaloid(taxane)
SE: diarrhea/Mucositis

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Doxil (doxorubin liposomal)

Metastatic ovarian, Kaposi’s, breast
Antitumor ATB
SE: n/v/d/mucositis, hand foot sx
turns urine red

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Adriamycin(doxorubin)

breast, gastric, HN, lung, liver, kidney ALL and many more
Anthracycline ATB
SE: n/v/d/mucositis/hand foot sx, anorexia, “red devil”
Give Omega 3s/CoQ 10/Theanine- may reduce toxicity

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Vinorelbine(navelbine)

breast, ovarian, lung
Plant alkaloid
SE: constipation, stomatitis
a/n/v

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Etoposide

lung, gastric, testicular, bladder prostate
Plant Alkaloid (cell cycle specific)
SE: Metallic taste, a/n/v/d

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Herceptin (Trastuzumab)

metastatic breast cancer HER2/NEU
Monoclonol ATB
SE: n/v/d
avocados, olive oil increase sensitivity to drug

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xgeva (denosumab)

injection

To prevent skeletal related events
Monocolonal ATB RANK inhibitor
SE: n/v/d, decreased Calcium
Osteonecrosis of jaw

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Carboplatin (paraplatin)

HN, bladder, ovarian, lung endo
Alkylating agent
SE: n/v, peripheral neuropathy

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Treanda (bendamustine)

CLL, NHL
Alkylating agent
SE: n/v/f
Tumor lysis syndrome

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Iressa

oral

NSCLC
Protein target tx- tyrosine kinase inhibitor EGFR
SE: n/v/d, decrease appetite, hand-foot sx
Take with WATER

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Kadcyla

HER2+ metastatic breast
Monoclonal ATB
SE: Constipation, increased liver enzymes, n/f

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List 3 Aromatase Inhibitors

Anastrozenole (Arimidex)
Aromasin(exemestane)
Femara
SE: hot flashes, fatigue, joint pain, blood clots, muscle aches, elev. chol, BONE LOSS
AntiEstrogens
Counsel to promote bone strength (calcium, vit D, exercise)

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Zometa

bone mets

Need 500 mg Calcium and 400 IU Vit D daily

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Vincristine (oncovin)

leukemia, lymphoma, Multiple Myeloma, brain
Plant Alkaloid (cell cycle specific)
SE: SEVERE CONSTIPATION, Jaw pain, decreased appetite
AVOID: SJ WORT, GRAPEFRUIT

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Vinblastine (Velban)

breast, testicular, HN, lymphoma
Plant Alkaloid (cell cycle specific)
SE: mucositis, stomatitis, severe constipation, jaw pain
AVOID: SJ WORT, GRAPEFRUIT

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TORISEL

oral

advanced renal cell
mTOR inhibitor
SE: hyperglycemia, elevated cholestrol

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Tamoxifen (nolvadex)

oral

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Breast
Anti Estrogen
SE: hot flashes, N/V/wt gain
AVOID: SJ WORK AND GRAPEFRUIT
Take calcium and vit d

Nexavar

oral

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liver, kidney
protein targeted tx, tyrosine kinase inhibitor
SE: n/v/d/a, hand-foot sx, white hair
TAKE ON EMPTY STOMACH 
AVOID SJ WORT

Streptozocin(Zanosar) | IV

pancreas, carcinoid Alkylating Agent, Vesicant SE: HYPOGLYCEMIA, N/V

PROVENGE (Sipuleucel T) | IV

``` metastatic prostate Autologous cellular immunotherapy SE: CHILLS AVOID CAFFEINE TAKE WITH CALCIUM ```

Stivarga (regorafenib) | Oral

colon SE: n/v/d/a/mucositis TAKE WITH A LOW FAT MEAL

Matulane (procarbazine hydrochloride) | oral

hodgkins, NHL, brain tumors Alkylating agent SE: CONSTIPATION, dry mouth FOLLOW A LOW TYRAMINE DIET, NO GINSENG

Alimta (premetrexed) | injection

lung, mesothelioma SE: n/v/d/f/severe anemia GIVE FOLIC ACID AND B12

``` 5 FU (flouracil) IV ```

``` breast, colon, GI, HN, pancreas, ovarian Antimetabolite(cell cycle specific) SE: n/v/d/mucositis GIVE B6 TO AVOID HAND/FOOT SX Have patients hold ice chips in the mouth to 15 minutes pre-and post IV to reduce incidence of oral mucositis ```

mercaptopurine (6-MP) | oral

leukemias, lymphomas Antimetabolite (cell cycle specific) SE: n/v/d/mucositis, hyper uricemia, liver toxicity AVOID DAIRY/ TAKE ON EMPTY STOMACH

Velcade (bortezomib) | iv

multiple myeloma Protease inhibitor NO GREEN TEA

Targretin (bexarotene) | oral

T cell lymphoma(myocosis fungoids) NO GRAPEFRUIT LIMIT VITAMIN A TO <= 150mg/day

Bulsulfan (myleran | oral

CML alkylating agent SE: n/v/d, mucositis AVOID ASPIRIN

Alkeran (Mephalan) | oral

multiple myeloma, ovarian, breast, neuroblastoma Alkylating agent SE: n/v/d, mucositis TAKE ON EMPTY STOMACH

Leukeran (chlorambucil) | oral

pancreatic, CLL, lymphomas, breast, ovarian, testicular SE: n/v/hyperuricemia TAKE ON EMPTY STOMACH

Methotrexate | pill or injection

ALL, breast, lung, NHL, HN, bladder, osteosarcoma SE: n/mucositis, light sensitive AVOID FOLIC ACID AND ETOH TAKE ON EMPTY STOMACH

Oxaliplatin (eloxatin) | IV

colon, pancreatic, GI alkylating agent SE: n/v/d, SENSITIVE TO COLD B6 MAY DECREASE SEVERITY OF HAND/FOOT SX

Cisplatin (platinol) | IV

cervical, esophageal, lung, HN, ovarian, prostate, testicular alkylating agent SE: METALLIC TASTE, KIDNEY TOXICITY, HEARING LOSS n/v/low magnesium, low appetite HYDRATION IS IMPORTANT

XELODA (capecitabine) | oral

colon, metastatic breast SE: n/v/d, hand foot sx, GIVE B6 (50-100mg)TO REDUCE HAND FOOT SX TAKE WITHIN 30 MINUTES OF MEAL

Sprycel | oral

CML, ALL | AVOID SJ WORT, GRAPEFRUIT

Tarceva (erlotinib) | oral

NSCLC, metastatic pancreatic protein targeted tx: tyrosine kinase inhibitor SE: n/v/d/a, rash, hand foot sx NO GRAPEFRUIT OR ST WORT

Tykerb (lapatinib) | oral

``` HER 2+ met. breast Targeted tx: tyrosine kinase inhibitor SE: low, d/n/v/anemia NO GRAPEFRUIT TAKE ON EMPTY STOMACH ```

Afinitor (everolimus) | oral

breast, renal, neuroendocrine mTor kinase inhibitor AVOID SJ WORT AND GRAPEFRUIT

Exjade | oral

Oral IRON chelator contains lactose SE: diarrhea

Tasigna | oral

``` CML protein tyrokinase inhibitor NO GRAPEFRUIT TAKE ON EMPTY STOMACH CONTAINS LACTOSE ```

Gleevec | oral

CML, GIST SE: rash, hand-foot sx, n/v/d, decreased appetite can turn hair white AVOID SJ WORT AND GRAPEFRUIT

Temodar | oral

``` glioblastoma alkylating agent SE: N/V, fatigue, headache, photosensitivity, rash DO NOT CHEW OR CRUSH TAKE ON EMPTY STOMACH ```

Selective Estrogen Receptor Modulators | oral

Tamoxifen Evista Anti-Estrogens SE: hot flashes, n/v, wt gain

low tyramine diet

``` AVOID: alcohol caffeine raspberries figs dried fruit avocado banana miso soy sauce kraut aged cheese anchovies liver sausage bologna pepperoni ```

Arimidex

Increased risk of osteoporosis

Beta Carotene

when taken in high doses may increase risk of lung cancer

odynophagia

painful swallowing

FASS

Fat Acid Salt Sweet

Eribitux

Monitor magnesium and calcium levels closely especially in elderly

Chemo Drugs Flashcards

(55 cards)