Chemotherapeutic Agents Flashcards
1
Q
Chemo affecting fertility
A
Alkylating agents
High doses of cyclophosphamide & ifosfamide
High doses of cisplatin
Most chemo cause transient azoospermia
2
Q
Which chemo causes less nausea
A
Vincas, MTX, Asparaginase
3
Q
Chemo agent that works in G1 phase
What is G1 phase
A
Pre-replication
Asparaginase
4
Q
S phase
What happens
Which chemo
A
DNA synthesis
Cytarabine inhibits DNA polymerase
Steroids
Antimetabolites
- folic acid antagonists
- Pyrimidine antag eg. 5FU
- Purine antagonists eg. 6MP, mercaptopurine
5
Q
G2 phase
What happens
Which chemo
Mechanism
A
Pre mitosis
Topoisomerase inhibitors
Bleomycin
Cause DNA degradation
6
Q
M phase
Which chemo
Mechanism of action
A
Vinca alkaloids (vinblastine, vincristine)
Bind tubulin, interfere with formation of spindles
