Chemotherapy Flashcards
Does remission equate to curation?
No, as the patient can suffer relapse.
What does relapse indicate?
Failure of treatment
What can p53 mutations produce?
Cells which do not arrest as easily, making chemotherapy/radiotherapy less effective treatment in these patients.
What is a side-effect of vinca alkaloids?
Neuropathy
What is a side-effect of anthracyclines?
Cardiotoxicity
What is a side-effect of cis-platinum?
Nephrotoxicity
Where are tumor sanctuaries for evading chemotherapy?
Testis
BBB
What can limit the intensity of chemotherapy an individual can receive?
Myelosuppression
What is the difference between autologous bone marrow transplant and allogenic marrow transplant?
Autologous bone marrow transplant comes from the individual themself.
Allogenic bone marrow transplant comes from a donor (associated with a lower risk of relapse).
How do monoclonal antibodies work?
Affect cells that possess the target protein only.
Often used in combination with chemotherapy.
What form of leukaemia is linked with Philadelphia chromosome?
Chronic myeloid leukaemia
How is CML treated?
Tyrosine kinase inhibitors
