chemotherapy

Question 1

methotrexate(MTX)

Answer 1

MOA- competitively inhibits dihydrofolate reductase. in higher doses may inhibit protein synthesis
-cannot supplement folate with this drug when using it to tx CA

Question 2

microtubule inhibitors

Answer 2

vincristine
vinblastine
paclitaxel(taxol)
Docetaxel

*cholchcine- a gout medication- is a distant relative to theses drugs as far as MOA dealing with the microtubule inhibition

Question 3

tumor lysis syndrome

Answer 3

metabolic complications that occur during CA tx- esp with lymphoma & leukemia, Burkett’s, (ALL, AML)

• caused by the breakdown products of dying cancer cells
• can induce renal shut down
• complications- hyperkalemia, hyperphosphatemia, hypocalcemia, hyperuricemia, hyperuricosuria, uric acid nephropathy, acute renal failure
• prophylactic tx- oral or IV allopurinol(inhibits uric acid), adequate IV hydration to maintain a high urine output(>2.5L/day)

Question 4

Tamoxifen

Answer 4

Estrogen antagonist