Chemotherapy Flashcards
(40 cards)
Cell membrane inhibitors
TIPP Triazoles Imidazole Polyenes; fungi Polymyxins; gram-
Protein synthesis inhibitors
Line takes Anton's Mac for chemistry Lincosamides Tetracycline Aminoglycosides Macrolides Fusidic acid Chloramphenicol
Nucelic acid synthesis inhibitors
Quinn’s rifle fires three souls. Quinn smokes cigars and pipes. This happens during the nuclear wear.
Quinolone; ciprofloxacin, pipemidic acid Rifamycin; rifampin Fusidic acid Trimethoprim Sulfonamide
B-lactamase inhibitors
When lactating, children sucks on your Tatars.
Clavulanic acid
Sulbactam
Tazobactam
Antileprotic drugs
Mina cyclet under klar himmel, hun treffer på et reef... Uflax! Klo fast i Mine, Dapsoone. Minocycline Clarithromycin Rifampicin Ofloxacine Clofazimine Dapsoone
Bactericidal
Kills bacteria MBC, minimal bactericidal concentration. AB(...cde)FG Aminoglycosides - cons.dep B-lactams - time dep. Fluroquionolones - cons.dep Glycopeptides
Bacterostatic
Inhibits bacterial growth
MIC: time above
Good efficiency: b-lactams and macrolides
AUC, area under curve; azythromycine
Lincosamides Chloramphenicol Macrolides Tetracycline Ketolides Sulfonamides
Penicillins
Cell wall
High affinity for B-lactams
Cell wall synthesis inhibitors
B-lactames; penicillin, cephalosporins
Polypeptides; bacitracin
Glycopeptides; teicoplanin, daptomycin, vancomycin
Fosfomycin
Penicillins, natural + bacteria
Benzylpenicillin G
Phenoxymethylpenicillin V
Strep+staph, Takes a trip to Nigeria Close to Benin
Streptococcus spp. penicillianse (-) Staphylococcus spp. Treponema Neisseria Clostridium Bacillus
Penicillins, semisynthetic + bacteria
Isoxazolyl penicillins: Drugs: meth, coke, fluor Methycillin Cloxacillin Dicloxacillin Flucloxacillin
- Staph +&-
Penicillins with broad spect.
Aminopenicillins
Aminopenicillins: - Ampicillin - Amoxycillin Like penicillin G Staph+strep takes a trip to Nigeria close to Benin + HELME: Haemophulus Enterococcus Listeria Moraxella Enterobacteriacae
Penicillins with broad spect.
Carboxy-, ureido
Piper likes Carbs like Macaroni, Tikka, Aioli -Piperacillion -Carbapenem -Mezlocillin -Azlocillin -Ticarcillin \+ Acinetobacter Pseudomonas
Penicillins with broad spect.
With inhibitors of B-lactamases
Ampicillin/sulbactam
Amoxycillin/clavulanic acid
Ticaracilin/clavulanic azid
Piperacilin/tazobactam
4 groups of penicillins
- Highest act against G+, spirochetes - suspectible to hydrolysis by B-lactamases and acid-lable.
Penicillin G - Lower act against G+, inactive G-, relative resistance to B-lactamases.
Nafcillin - High act against G+ and G-, destroyded by B-lactamases.
Ampicillin, piperacillin - Stable to gastric acid, oral adm.
Penicillin V, cloxacillin, amoxicillin
Cefalosporins
- activity
Inactive: Enterococcus, listeria, MRSA, most anaerobes.
Penetrate CNS
Good tolerance
Susceptibility to B-lactamases
Cefalosporins
I. gen
Cefalotin Cefazolin Cefradine Cefadroxyl Cefalexin
Strep(+), staph PEK Proteus E.coli Klebsiella
Cefalosporins
II.gen
Cefaclor Cefuroxim Cefamandol Cefprozil \+ Haeomphilus Moraxella+
Cefalosporins
III.gen
More resistant to B-lactamases Penetrate into CNS Cefotaxime Cetriaxone Ceftazidime Cefoperazon \+ Acinetobacter Pseudomonas
Orally: inactive against pseudomonas, less active staph.
Cefalosporins
IV.gen
More active to staph
More resistant to B-l
Cefepime
Cefpirome
Cefalosporins
V. gen
Ceftaroline
Anti-MRSA
Seff tar ho Line MRSA
Monobactams
Aztreonam G(-) aerobes Haeomphilus Neisseria G(-) rods
Carbapenems
spiser du Erter må du Mer Inni Do Ertapenem Meropenem Imipenem Doripenems
Highest act G+/- aerobes, anaerobes, enterococci.
INACTIVE: MRSA, Jeikeium Faecium Burkholderia Stenotrophomonas
Bacterostatic 50S
Spectrum
Ketolides
Azalides
Macrolides
Atypical bacteria: Chlamydia Mycoplasma Legionella Ureaplasma Rikettsia
Side effects:
Nausea
Vomiting
Diarrhoea
