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PHRM 844 Exam 2 > Chen - Women's Health > Flashcards

Chen - Women's Health Flashcards

1
Q

Menopause Diagnosis

A

12 consecutive months of amenorrhea

Increased LH and FSH

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2
Q

Menopause Diagnosis

A

12 consecutive months of amenorrhea

Increased LH and FSH

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3
Q

postmenopause

A

time after the period stops

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4
Q

Premature menopause

A

occurs before age 40

due to hysterectomy, radiation, chemo

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5
Q

Indications for hormonal therapy in menopause

A

vasomotor symptoms
vulvovaginal atrophy
osteoporosis prevention

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6
Q

CI to hormonal treatment

A 
bleeding
pregnancy
breast/endometrial cancers
stroke 
liver disease 
thrombo disorder
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7
Q

Mono oral estrogens

A

premarin
menest
estrace
*tend to have more side effect

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8
Q

Who can have estrogen monotherapy

A

ONLY women WITHOUT a uterus

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9
Q

Oral hormonal combos

A 
prempro
angeliq
jinteli
activella
mimvey
prefest
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10
Q

Hormonal patches

A 
menostar
alora
climara
minivelle
vivelle 
*who the f names this shit
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11
Q

Vaginal tablets

A

*only used for vaginal symptoms like dryness
vagifem
yuvafem

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12
Q

vaginal rings (and their difference)

A

Estring - smaller

Femring - bigger - requires a progesterone with it

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13
Q

Vaginal creams

A

*only for vaginal atrophy
estrace
premarin

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14
Q

WHI study findings for combo products

A

Increased risk of heart attack, stroke, thrombembolisms, breast cancer, dementia
Decreased risk of colorectal cancer, hip fractures

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15
Q

WHI study findings for estrogen mono

A

higher risk of stroke and embolism

lower risk of hip fractures

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16
Q

WHI study findings for age group

A

For least amount of risk, hormonal therapy should be started before age 60 or within 10 years of the last period

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17
Q

Continuous cyclic administration

A

daily estrogen + 12-14 days progesterone in a 28 day cycle
scheduled bleeding - good in recently menopausal women
HIGHER ENDOMETRIAL CANCER RISK
premphase, combipatch

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18
Q

Continuous Long Cycle Administration - rare

A

estrogen daily + 12-14 days progesterone every other month

HIGHER ENDOMETRIAL CANCER RISK

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19
Q

Continuous Combined Administration - most common

A

estrogen + progesterone daily
best endometrial protection
no bleeding - for women >2 years postmenopause
Prempro, jinteli, angeliq, activella, mimvey, combipatch, climara pro

20
Q

Intermittent Combined Administration

A

Estrogen daily + progesterone 3 days on and 3 days off
good if having SEs from daily progesterone
unknown endometrial risk
prefest

21
Q

Duavee

A 
estrogen + SERM
bone agonist - helps with osteoporosis
breast + uterus antagonist - cancer prevention
treats vasomotor
can increase CV risk 
less hormonal symptoms
22
Q

Non-hormonal Vasomotor Treatment

A

SSRIs : paroxetine, citalopram, escitalopram

SNRIS: ven and desvenlafaxine

23
Q

Osphena

A

treats dyspareunia - painful sex due to vaginal dryness
causes hot flashes
same CIs of estrogens

24
Q

intrarosa

A

treats dyspareunia

very expensive

25
Q

postmenopause

A

time after the period stops

26
Q

Premature menopause

A

occurs before age 40

due to hysterectomy, radiation, chemo

27
Q

Indications for hormonal therapy in menopause

A

vasomotor symptoms
vulvovaginal atrophy
osteoporosis prevention

28
Q

CI to hormonal treatment

A 
bleeding
pregnancy
breast/endometrial cancers
stroke 
liver disease 
thrombo disorder
29
Q

Mono oral estrogens

A

premarin
menest
estrace
*tend to have more side effect

30
Q

Who can have estrogen monotherapy

A

ONLY women WITHOUT a uterus

31
Q

Oral hormonal combos

A 
prempro
angeliq
jinteli
activella
mimvey
prefest
32
Q

Hormonal patches

A 
menostar
alora
climara
minivelle
vivelle 
*who the f names this shit
33
Q

Vaginal tablets

A

*only used for vaginal symptoms like dryness
vagifem
yuvafem

34
Q

vaginal rings (and their difference)

A

Estring - smaller

Femring - bigger - requires a progesterone with it

35
Q

Vaginal creams

A

*only for vaginal atrophy
estrace
premarin

36
Q

WHI study findings for combo products

A

Increased risk of heart attack, stroke, thrombembolisms, breast cancer, dementia
Decreased risk of colorectal cancer, hip fractures

37
Q

WHI study findings for estrogen mono

A

higher risk of stroke and embolism

lower risk of hip fractures

38
Q

WHI study findings for age group

A

For least amount of risk, hormonal therapy should be started before age 60 or within 10 years of the last period

39
Q

Continuous cyclic administration

A

daily estrogen + 12-14 days progesterone in a 28 day cycle
scheduled bleeding - good in recently menopausal women
HIGHER ENDOMETRIAL CANCER RISK
premphase, combipatch

40
Q

Continuous Long Cycle Administration - rare

A

estrogen daily + 12-14 days progesterone every other month

HIGHER ENDOMETRIAL CANCER RISK

41
Q

Continuous Combined Administration - most common

A

estrogen + progesterone daily
best endometrial protection
no bleeding - for women >2 years postmenopause
Prempro, jinteli, angeliq, activella, mimvey, combipatch, climara pro

42
Q

Intermittent Combined Administration

A

Estrogen daily + progesterone 3 days on and 3 days off
good if having SEs from daily progesterone
unknown endometrial risk
prefest

43
Q

Duavee

A 
estrogen + SERM
bone agonist - helps with osteoporosis
breast + uterus antagonist - cancer prevention
treats vasomotor
can increase CV risk 
less hormonal symptoms
44
Q

Non-hormonal Vasomotor Treatment

A

SSRIs : paroxetine, citalopram, escitalopram

SNRIS: ven and desvenlafaxine

45
Q

Osphena

A

treats dyspareunia - painful sex due to vaginal dryness
causes hot flashes
same CIs of estrogens

46
Q

intrarosa

A

treats dyspareunia

very expensive

PHRM 844 Exam 2 (10 decks)

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