Cholinergic agonists

Question 1

acetylcholine

Answer 1

direct cholinergic agonist
permanently charged quarternary ammonium –> no CNS absorption
intraocular use during surgery, rarely used systemically

Question 2

bethanechol

Answer 2

direct mAChR agonist
permanently charged quarternary ammonium –> no CNS absorption
treats urinary retention and heartburn

Question 3

carbachol

Answer 3

direct cholinergic agonist
permanently charged quarternary ammonium –> no CNS absorption
treats glaucoma

Question 4

cevimeline

Answer 4

direct cholinergic agonist

treats Sjogrens sx

Question 5

methacholine

Answer 5

direct cholinergic agonist

Question 6

pilocarpine

Answer 6

direct mAChR agonist
uncharged tert amine –> well absorbed
treats Sjorgens sx, glaucoma,

Question 7

varenicline

Answer 7

direct cholinergic agonist

used for smoking cessation

Question 8

neostrigmine

Answer 8

AChE inhibitor

quarternary and charged –> no CNS

Question 9

physostigmine

Answer 9

AChE inhibitor
tertiary and uncharged –> CNS effects
can reverse anticholinergic effects (ie vasodilation, anhidrosis, mydriasis, delirium) and is preferred b/c crosses BBB

Question 10

pyridostigmine

Answer 10

AChE inhibitor
quarternary and charged –> no CNS
pretx prevents nerve agent poisoning

Question 11

pralidoxime

Answer 11

AChE regenerator