Cholinergic Agonists and Antagonists

Question 1

What is the MOA of nicotine?

Answer 1

activation of neuronal nicotinic receptors

Question 2

What is the MOA of succinylcholine?

Answer 2

depolarizing block of muscle nicotinic receptors

Question 3

What is the MOA of acetylcholine?

Answer 3

nicotinic and muscarinic agonist

Question 4

What is the MOA of methacholine?

Answer 4

muscarinic agonist

Question 5

What is the MOA of carbachol?

Answer 5

nicotinic and muscarinic agonist

Question 6

What is the MOA of bethanechol?

Answer 6

muscarinic agonist

Question 7

What is the MOA of pilocarpine?

Answer 7

muscarinic agonist

Question 8

What is the MOA of neostigmine?

Answer 8

AChE inhibitor

Question 9

What is the MOA of edrophonium?

Answer 9

AChE inhibitor

Question 10

What is the MOA of physostigmine?

Answer 10

reversible AChE inhibitor

Question 11

What is the MOA of donepezil?

Answer 11

reversible AChE inhibitor

Question 12

What is the MOA of pralidoxime?

Answer 12

peripheral AChE reactivator

Question 13

What is the MOA of echothiophate?

Answer 13

irreversible AChE inhibitor

Question 14

What is the MOA of atropine?

Answer 14

muscarinic antagonist

Question 15

What is the MOA of scopolamine?

Answer 15

muscarinic antagonist

Question 16

What is the MOA of glycopyrrolate?

Answer 16

muscarinic receptor antagonist

Question 17

What is the indication for nicotine?

Answer 17

withdrawal symptoms of smoking cessation

Question 18

What is the indication for succinylcholine?

Answer 18

neuromuscular block for electroconvulsive shock therapy or emergency intubation

Question 19

What is the indication for acetylcoline?

Answer 19

none

Question 20

What is the indication for methacholine?

Answer 20

diagnosis of subclinical asthma or test for severity of asthma

Question 21

What is the indication for carbachol?

Answer 21

miotic agent in ocular surgery to reduce pressure following ocular surgery

Question 22

What is the indication for bethanechol?

Answer 22

urinary retention, bladder atony

Question 23

What is the indication for pilocarpine?

Answer 23

dry mouth from head and neck radiation or Sjogren’s syndrome; narrow angle glaucoma

Question 24

What is the indication for neostigmine?

Answer 24

myasthenia gravis, reversal of neuromuscular block

Question 25

What is the indication for edrophonium?

Answer 25

diagnosis of myasthenia gravis, reversal of neuromuscular block

Question 26

What is the indication for physostigmine?

Answer 26

delirium from anticholinergic drugs, glaucoma

Question 27

What is the indication for denopezil?

Answer 27

diagnosis of Alzheimer's

Question 28

What is the indication for pralidoxime?

Answer 28

respiratory muscle weakness in organophosphate poisoning

Question 29

What is the indication for echothiophate?

Answer 29

open angle glaucoma

Question 30

What is the indication for atropine?

Answer 30

excess secretions during surgery, increased frequency and urgency associated w/ cystitis, hypertonic gut, organophosphate poisoning, bradycardia

Question 31

What is the indication for scopolamine?

Answer 31

motion sickness, anti-salilagogue in surgery

Question 32

What is the indication for glycopyrrolate?

Answer 32

protects against excessive muscarinic activation during reversal of neuromuscular blockade, anti-salilagogue

Question 33

What is the HL of acetylcholine? How is it eliminated?

Answer 33

~150 msec; AChE

Question 34

How is succinylcholine broken down?

Answer 34

butyrl cholinesterase

Question 35

What is the HL of pilocarpine?

Answer 35

~1 hr

Question 36

What is the HL of edrophonium?

Answer 36

~10 mins

Question 37

What is the HL of pralidoxime?

Answer 37

~75 mins

Question 38

What is the HL of echothiophate?

Answer 38

not exactly known, but very long