Cholinergics (Parasympathetic)

Question 1

BOTOX action and uses

Answer 1

ACTION -
Blocks Ach release (M receptor)

USES - Blepharospasm

     - Torticollis (neck)
     - Achalasia cardia
     - Cosmetic
     - Squint

Question 2

Reuptake of choline inhibited by

Answer 2

HEMICHOLINIUM

Question 3

Pilocarpine

Answer 3

Direct acting cholinergic

USES : Glaucoma
Sjörgen’s Syndrome
Meiosis of Pupil (constriction)

Question 4

Direct acting cholinergics on Periphery

Answer 4

BMC

BETHENECOL -Bowel (⬆️GI pstls)
-Bladder (⬆️urination)

CARBACHOL - common action on Nicotinic and Muscarinic receptors

METHACHOLINE - heart(M2) - 🔻HR

Question 5

Anticholinesterases
(Or)
Indirect acting cholinergics

“stigmines”

Answer 5

Tx. Alzheimers(🔻Ach)
      Myasthenia gravis (🔻Ach)
      Atropine toxicity, Crurare
      Dathura, Belladona toxicity 
      Cobra bite

PHYSOSTIGMINE
NEO/PYRIDOSTIGMINE
DONEPEZIL
RIVASTIGMINE

Question 6

Alzheimers dementia Tx

Answer 6

DONEPEZIL

Question 7

Atropine toxicity tx

Answer 7

PHYSOSTIGMINE

Question 8

Dathura and Belladona toxicity tx

Answer 8

PHYSOSTIGMINE

Question 9

Cobra bite Tx.

Answer 9

NEO / PYRIDOSTIGMINE

Question 10

Hepatotoxic anticholinesterase

Answer 10

TACRINE

Question 11

Myasthenia gravis DX. & TX.

Answer 11

Dx. : Tensilon Test - EDROPHONIUM

Tx : NEO / PYRIDOSTIGMINE

Question 12

Effect of Poisons

Organphosphates (irreversible)

Carbamates (reversible)

Answer 12

DUMBBELLS

Diarrhea (M3)
Urination (M3)
Miosis (M3)
Bronchoconstriction (M3)
Bradycardia (M2)
Emesis (M1)
Lacrimation (M3)
Lethargy (Nm)
Salivation (M3)

⬆️⬆️⬆️⬆️ Ach - ⬆️⬆️⬆️⬆️PS activity

Question 13

Cause of death in Organophosphate poisoning

Answer 13

Lethargy (Nm)

DESENSITISATION of Nm receptor cause FLACCID PARALYSIS and Pt. dies of RESPIRATORY FAILURE

Question 14

Organophosphate poisoning Tx.

Answer 14

ATROPINE + PRALIDOXINE

action: 🔻🔻PS activity

Question 15

Carbamate poisoning Tx.

Answer 15

ATROPINE only

Action: 🔻🔻PS activity