Cholinesterase Inhibitor

Question 0

Physostigmine

Answer 0

Cholinesterase Inhibitor
Carbamate Tertiary amine
AChase
Reversible COVALENT bone with AChase (30min-6hr effect)
Crosses the BBB-
rarely used - may be applied topically for Glaucoma

Question 1

Neostigmine

Answer 1

Cholinesterase Inhibitor
Carbamate Quaternary Amine
AChase
Reversible COVALENT bone with AChase (30mins-6hr effect)
Does not cross the BBB, prophylactic to organophosphate poisoning, used to treat MG and END neuromuscular block (non-depol)

Question 2

Edrophonium

Answer 2

Cholinesterase Inhibitor
Alcohol with quaternary ammonium
AChase
Reversible VERY short duration of action (5-10mins)
–used in myasthenia gravis, tailor drug therapy, End neuromuscular blockade caused by NON-depolarizing channel blockers

Question 3

Echothiophate

Answer 3

Cholinesterase Inhibitors 
Organophosphate 
AChase 
Reversible Long Action 
Used for long action tx of glaucoma

Question 4

Donepezil/Rivastigmine

Answer 4

Cholinesterase Inhibitor
NO CLASS
AChase
Similar to Phyostigmine, used to treat alzheimers

Question 5

Organophosphates

Answer 5

Cholinesterase Inhibitor 
Pesticide 
AChse 
-Reversible at first and long lasting
- irreversible after "Aging" of bond 
-Side Effects: SLUDGE and MUSCARINIC EFFECTS

Question 6

Praledoxime

Answer 6

Cholinesterase Inhibitor
NO CLASS
Organophosphate
-binds to phosphate of organophosphate to prevent aging if added in time
- need to adminster slowly because it has toxic effects of its own-