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Pharmacology > Cholinomimetics > Flashcards

Cholinomimetics Flashcards

(55 cards)

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1
Q

A drug that acts by STIMULATING the PARASYMPATHETIC NERVOUS SYSTEM. Increase cholinergic outflow

A

Cholinomimetics

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2
Q

Direct Acting Choline Esters are …

A

A - Acetylcholine
B - Betanechol
C - Carbachol

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3
Q
  • Muscarinic agonist
  • Activates M1 to M3 receptors
  • Increased secretion, smooth m contraction (except in vascular smoot muscles : relaxation)
  • Changes HEART RATE
A

Acetylcholine

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4
Q

Adverse Effect: Cytospasm, diarrhea, urinary urgency, vasodilation, reflex tachycardia, sweating

A

Betanechol and Carbachol

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5
Q

Very short lived direct acting choline esters

DOA: 5 - 30 seconds

A

Acetylcholine

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6
Q

Rapidly hydrolyzes by AChE

A

Acetylcholine

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7
Q

Acts on Both M and N receptor except

Acetylcholine
Betanechol
Carbachol

A

Betanechol (M receptor only)

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8
Q

Used topically for glaucoma treatment

A

Carbachol

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9
Q

Used for bladder and bowel atony

A

Betanechol

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10
Q

Adverse effect:

CNS stimulation, miosis, cyclospasm, bronchoconstriction, excessive GI and GU SM contraction, increased secretory activity of sweat glands, airways, vasodilation

A

Acetylcholine

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11
Q

Neurotransmited used by PNS

A

Acetylcholine

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12
Q

Resistant to AChE

A

Betanechol

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13
Q

Muscarinic agonist, activates M1 to M3 except

Acetylcholine
Betanechol
Carbachol

A

Carbachol

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14
Q

Acts on M receptor only

A

Betanechol

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15
Q

Direct acting choline ester with DOA: 30mins - 2hrs

A

Carbachol

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16
Q

Direct Acting Nicotinic Agonist are …

A

N - Nicotine

V - Varenicline

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17
Q

Nonselective muscarinic and nicotinic agonist

A

Carbachol

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18
Q

Adverse Effect: Miosis, blurring of vision

A

Pilocarpine

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19
Q

Direct acting muscarinic ALKALOIDS

A

Pilocarpine

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20
Q

Good lipid solubity compared to choline esters

A

Pilocarpine

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21
Q

Used for treatmenr of Glaucoma, Sjorgen, Sicca syndrome

A

Pilocarpine

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22
Q

A direct acting nicotinic agonist at both NN and NM receptors

Activates autonomic post ganglionuc neurons and skeletal m neuromuscular end plates

A

Nicotine

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23
Q

For smoking cessation

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A

Nicotine

Varenicline (exclusively)

24
Q

Adverse effect: Generalized ganglionuc stimulation (Hypertension, tachycardia, nausea, vomiting, diarrhea)

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A

Nicotine

Verenicline

25
Able to ENTER the CNS and activates NN receptor
Nicotine
26
A directing acting nicotinic agonist with DOA: 1-6hrs only
Nicotine
27
A directing acting nicotinic agonist with DOA: 12-24h
Varenicline
28
Short Acting Cholinesterase Inhibitor (Alcohol) is ...
Edrophonium
29
It binds briefly to activate site of AChE and preventa access of Ach
Edrophonium
30
ADVERSE EFFECT: miosis, salivation, nausea, vomiting, diarrhea, bradycardia
EDROPHONIUM (short acting cholinesterase inhibitor) Intermediate Acting Cholinesterase Inhibitor N - Neostagmine P - Pyridostigmine P - Physostigmine Long Acting Cholinesterase inhibitor M - Malathion E - Echothiophate P - Palathion
31
Amplifies all actiona of Ach
Edrophonium
32
For Myasthenia gravia diagnosis (Tensilon test)
Edrophonium
33
A parenteral drug that is very short lived (DOA: 5-15mins)
Edrophonium
34
Increases parasympathetic activity and somatic neuromuscular transmission
Edrophonium
35
Intermediate Acting Cholinesterase Inhibitor (Carbamates) is ...
N - Neostaine P - Pyridostigmine P - Physostigmine
36
Forms covalent bonds with AChE, but hydrolyzed and released
Neostagmine
37
An intermediate acting cholinesterase inhibitor (carbamates) that is LONGER acting than Edrophonium (short acting cholinesterase inhibitor)
Neostagmine
38
An intermediate acting cholinesterase inhibitor (carbamates) that is LONGER acting effect compared to neostagmine
Pyridostigmine
39
An intermediate acting cholinesterase inhibitor (carbamates) that is used for TREATMENT of Myastenia Gravis
Neostagmine
40
Reversal of nondepolarizing muscular blockade
Neostagmine
41
Used for treatment of Ogilvie Syndrome (an acute colonic pseudo-obstruction)
Neostagmine
42
A intermediate acting cholinesterase inhibitor with poor lipid solubity
Neostagmine | Pyridostigmine
43
A intermediate acting cholinesterase inhibitor DOA: 30min - 2h Oral
Neostagmine
44
A intermediate acting cholinesterase inhibitor DOA: 4-8h Oral
Pyridostigmine
45
A intermediate acting cholinesterase inhibitor with good lipid solubility
Physostigmine
46
A intermediate acting cholinesterase inhibitor that is able to enter the CNS DOA: 4-8hrs
Physostigmine
47
Long Acting cholinesterase inhibitor (Organophosphates)
M - Malathion E - Echothiophate P - Palathion
48
A natural alkaloid tertiary amine, similar to neostagmine
Physostigmine
49
Similar to physostigmine but slowet release
Echothiophate
50
Moderate lipid solubility
Echothiophate
51
A ling acting cholinesterase inhibitor with DOA: 2-7days
Echothiophate
52
Scabicide
Malathion
53
Insecticide
Parathion
54
High lipid solubity
Malathion | Parathion
55
A long acting cholinesterase inhibitor with DOA: 7-30days
Malathion | Parathion

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