Chp. 2 Granulomatous Inflammation Flashcards Preview

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Flashcards in Chp. 2 Granulomatous Inflammation Deck (11):
1

Granulomatous inflammation is a ___of chronic inflammation

Subtype

2

What is granulomatous inflammation characterized by?

It is characterized by granuloma formation

3

What is a granuloma?

A granuloma is a collection of EPITHELIOD HYSTIOCYTES
usually surrounded by giant cells and a rim of lymphocytes.

4

What are epitheliod histiocytes?

These are the hallmark cells of granuloma formation and they are activated macrophages with abundant pink cytoplasm.

5

What two types are granulomas divided into?

Caseating and non caseating

6

Describe noncaseating granulomas. What are they commonly due to?

Non caseating granulomas LACK CENTRAL NECROSIS.

They are commonly due to:
Reaction to foreign material
Sarcoidosis
Be Exposure
Crohns
Cat Scratch (Bartonella Henselae)

7

What is caseating granulomas and what are they commonly due to?

These are granuloma WITH CENTRAL NECROSIS and are characteristic of TB and fungal infections

8

What are the steps for granuloma formation?

1. Macrophages process and present Ag to CD4+ Helper on MHC II. CD4+ binds the Ag

2. Once CD4+ binds the Ag, the Macrophage will release IL-12.

3. IL-12 from macrophage induces CD4+ to differentiate into the Th1 SUBTYPE

4. Th1 cells secrete IFN-y.

5. IFN-y converts macrophages to EPITHELIOID HISTIOCYTES AND GIANT CELLS.

9

What is a giant cell?

It is a fusion of macrophages (or other cells) with a bunch of nuclei

10

What cytokine is responsible for inducing CD4+ into Th1 subtype?

IL-12

11

What cytokine is necessary for the production of epithelioid histiocytes?

IFN-y. Also turns macrophages into giant cells.