Chron's vs Ulcerative Cloitis

Question 1

Induction of remission for:

Ulcerative Colitis

Answer 1

• 5-ASA +/- steroids or thiopurine
• anti-TNF +/- thiopurine
• IV cyclosporine
• tofacitinib

Question 2

Induction of remission for:

Chron’s

Answer 2

• steroids +/- thiopurine or mtx
• anti-TNF +/- thiopurine
• interleukin receptor antagonist

Question 3

IBD and IBS difference

Answer 3

IBD causes inflammation IBS does not

Question 4

Chrohn’s maintenance therapy

Answer 4

Mild disease:
- Oral Budesonide for < 3 months followed by thiopurine or mtx

Mod-Severe disease

• anti-TNF [adalimumab (Humira), infliximab (Ramicade), certolizumab (Cimzia)]
• Thiopurine (Azathioprine, Mercaptopurine)
• Methrotrexate
• IL receptor antagonist [ustekinumab (Stelara)]

Refractory
- Integrin receptor antagonist (vedolizumab, natalizumab)

Question 5

Ulcerative colitis maintenance therapy

Answer 5

Mild
- Mesalamine (5-ASA)

Mod-Severe

• anti-TNF [adalimumab (Humira), infliximab (Ramicade), certolizumab (Cimzia)]
• Thiopurine (Azathioprine, Mercaptopurine)
• Cyclosporine
• Janus kinase inhibitor (tofacitinib)

Refractory
- Integrin receptor antagonist (vedolizumab)

Question 6

Which steroids are preferred in the treatment of Chron’s and/or UC?

Answer 6

Budesonide

Prednisone

Question 7

What is the difference b/w Chron’s disease and Ulcerative Colitis?

Answer 7

• Ulcerative Colitis involves the Colon and Rectum and Chron’s involves the entire GI tract
• Ulcerative Colitis is superfical while Chron’s is Treasmural
• Ulcerative Colitis is continuous while Chron’s is non-continuous

Question 8

Some common brand names for Mesalamine

Answer 8

Apriso
Pentasa
Delzicol 
Asacol 
Rowasa
Canasa

Question 9

Aminosalicylate agents

Answer 9

Mesalamine

Sulfasalazine

Question 10

Thiopurine agents

Answer 10

Azathioprine

Mercaptopurine