Chronic

Question 1

List 3 causes of chronic inflammation

Answer 1

1. Persistent infections
2. Hypersensitivity disease (Type 4, or severe Type 1 to allergies)
3. Prolonged exposure to toxic agents (endogenous or exogenous)

Question 2

What is granulomatous inflammation?

Answer 2

A type of chronic inflammation, occurs especially when the causative agent of the response is difficult to eradicate/digest.

Characteristic features:
1. Granulomas - epitheloid histocytes
2. Multinucleated giant cells - arise becos of lymphocytes that secrete cytokines, triggering histocytes to aggregate together

Question 3

Granuloma VS granulation

Answer 3

Granuloma: aggregate of epithelioid histocytes

Granulation: Important components of healing and compromises small blood vessels in a connective tissue

Question 4

Where are epitheloid histocytes derived from?

Answer 4

Macrophage