Ciulla Review Questions Flashcards
(20 cards)
What is the first type of cell produced by the developing embryo?
Erythrocyte
What percentage of tissue located in the bone marrow cavities of adults is fat?
50%
Which of the following is not characteris- tic of pluripotent hematopoietic stem cells?
Express the stem cell marker CD 13
In an adult, what are the two best areas for obtaining active bone marrow by aspiration?
Posterior iliac crest, sternum
What is the normal ratio of myeloid to erythroid precursors in bone marrow (M:E ratio)?
4:1
Which of the following does not accurately describe hematopoietic growth factors?
Action of majority is lineage restricted
In the third month of gestation, what is the primary site of hematopoiesis?
Liver
The mechanism that relays information about tissue oxygen levels to erythro- poietin-producing sites is located in the
Kidney
Antigen-independent lymphopoiesis occurs in primary lymphoid tissue located in the
Thymus and bone marrow
Programmed cell death is called
Apoptosis
In what area of the bone marrow does hematopoiesis take place?
Cords
Bone marrow cellularity refers to the ratio of
Hematopoietic tissue to adipose tissue
Interleukins and colony stimulating factors are cytokines produced by
Monocytes and T lymphocytes
What is the approximate total blood volume in an adult?
6 L
The myeloid progenitor cell can produce cells committed to
Granulocytic, erythrocytic, monocytic,
or megakaryocytic lineages
The largest hematopoietic cells in normal bone marrow are
Megakaryocytes
When evaluating a bone marrow aspirate smear, which finding is considered abnormal?
The presence of 10% myeloblasts on
the cell differential count
As most blood cell lines mature, which of the following is characteristic?
Nucleus to cytoplasm ratio (N:C) decreases
Which of the following describes thrombopoietin (TPO)?
Hormone produced by the liver that
stimulates megakaryopoiesis
When the hepatic phase of fetal life is reactivated in an adult, hematopoiesis can be termed
Myeloid metaplasia or extramedullary
