CKD

Question 1

Non Duhydropyridine CCB

Answer 1

• Verapamil and DIltiazem*
  proteinuric effect
  slow progression on CKD
• do not combine with beta-blockers

Question 2

Dihydropyridine CCB

Answer 2

• Amlodipine and Nifedipine*
• no effect on proteinuria
• risk of edema

Question 3

Lotensin

Answer 3

Benazepril
start dose: 5 mg qd
max dose: 80 mg
60 & renal 40% biliary

Question 4

Capoten

Answer 4

Captopril

50% renal and 50% hepatic

Question 5

Vasotec

Answer 5

Enalapril

95% renal

Question 6

Monopril

Answer 6

Fosinopril

50% renal and 50% hepatic

Question 7

Zestril/Prinivil

Answer 7

Lisinopril

100% renal

Question 8

Moexipril

Answer 8

Univasc

7% urine and 63% feces

Question 9

Accupril

Answer 9

Quinapril

96% renal

Question 10

Altace

Answer 10

Ramipril

60% renal and 405% feces

Question 11

Mavik

Answer 11

Trandolopril

33% urine and 66% feces

Question 12

Edarbi

Answer 12

azilsartan

55% feces and 42% urine

Question 13

Atacand

Answer 13

Candestartan

65% hepatic and 35% renal

Question 14

Teveten

Answer 14

Eprosartan

90% feces and 7% urine

Question 15

Avapro

Answer 15

Irbesartan

80% hepatic and 20% renal

Question 16

Coozar

Answer 16

Losartan

60% feces and 40% urine

Question 17

Benicar

Answer 17

Olmasartan

50% feces and 50% urine

Question 18

Micardis

Answer 18

Telmisartan

97% feces

Question 19

Diovan

Answer 19

Valsartan
84% feces
13% urine

Question 20

Aliskiren

Answer 20

Brand: Tekturna

• direct renin inhibitor
• contraindications: pregnancy, combination with ACE/ARBS

Question 21

RAAS absolute contraindications

Answer 21

• pregnancy
• Bilateral renal artery stenosis
• history of ACE/ARBS related angioedema

Question 22

RAAS dose adjustment based on GFR

Answer 22

GFR 0-15% no change
15-30% no change
30-50: cut dose in half and check in a week
>50% hold therapy

Question 23

RAAS side effects

Answer 23

hypotension 
orthostasis 
dizziness
cough (more w arbs)
hyperkalemia 
angioedema

Question 24

RAAS and NSAID

Answer 24

AKI

Question 25

RAAS and K+

Answer 25

hyperkalemia

Question 26

RAAS x 2

Answer 26

AKI and Hyperkalemia

Question 27

SGLT 2 inh

Answer 27

"-glifozins" - aki - euglycemic diabetic ketoacidosis - UTI - lower limb amputations

Question 28

Allopurinol and Febuxostat

Answer 28

decrease uric acid ( goals is <7%) prevention: - 1.5 mg x eGFR - Stevens Johnson Syndrome

Question 29

Albuminuria

Answer 29

A1: <30 A2: 30-300 A3: >300

Question 30

GFR category

Answer 30

``` G1 Normal to high >90 G2: Mildly decreased 60-89 G3a Mild to moderately decreases 45-59 G3b: Moderately to severely decreased 44-30 G4: severely decreased 15-29 G5: Kidney failure <15 ```