CKD

Question 1

………is hypoglycemic drug that has risk of salt & water retention

Answer 1

Thiazodindione

Question 2

All patients with documented proteinuria should recieve…….., it is stopped if…….

Answer 2

ACEI or ARB
serum creatinine inc more than 30% from baseline

Question 3

Thiazide diuretics are ineffective in CKD if……, while …..are effective

Answer 3

Used alone in patients with GFR less than 30 ml/min/1.73 m2
Loop

Question 4

Describe management of anemia in CKD

Answer 4

1. Erythropoietin stimulating agents: epoetin alpha & darbepoetin (AEs: HTN/seizures)
2. Oral iron supplements
3. Vitamin B12 & folic acid

Question 5

Describe management of renal osteodystrophy

Answer 5

1. Active vitamin D
2. Restriction of dietary pjosphorus & phosphate binders
3. Cinacalcet: lowers intact PTH
4. Parathyroidectomy

Question 6

List indications of renal replacement therapy in CKD

Answer 6

1. Severe metabolic acidosis, hyperkalemia, intractable volume overload
2. Pericarditis & encephalopathy
3. Peripheral neuropathy, intractable GI symptoms
4. In asymptomatic adult patients, GFR of 5-9 ml/min/1.73m2

Question 7

List standard drug therapy of dialysis

Answer 7

1. Erythropoietin
2. Iron, parenteral during dialysis session
3. Vit D
4. Phosphorus binders
5. B-complex vitamin & folic acid & vit E to prevent muscle cramps & antihistamines